Overview

This is the analysis of white matter dsi studio connectometry for Maze and Loop

Methods

Participants
  • Total number of scans = 120 (males and females )
    • Total scans used in analysis= 118 *Exclude subs 329 and 372 from analyses
Scan parameters
  • Locations from UCSB and UCI
QSIprep
  • Version used: 0.16.0RC3
  • The following parameters were used
    • dwi_denoise_window 5
    • hmc_model 3dSHORE
    • hmc-transform Rigid
    • shoreline_iters 2

DSI Studio

Version and tags used chen-2022-07-31 A diffusion spectrum imaging scheme was used, and a total of 128 diffusion sampling were acquired. The maximum b-value was 4990 s/mm². The in-plane resolution was 1.8 mm. The slice thickness was 1.8 mm. The accuracy of b-table orientation was examined by comparing fiber orientations with those of a population-averaged template (Yeh et al. Neuroimage, 2018). The b-table was flipped by .012fy. The diffusion data were reconstructed in the MNI space using q-space diffeomorphic reconstruction (Yeh et al., Neuroimage, 58(1):91-9, 2011) to obtain the spin distribution function (Yeh et al., IEEE TMI, ;29(9):1626-35, 2010). A diffusion sampling length ratio of 1.25 was used. The output resolution in diffeomorphic reconstruction was 1.8 mm isotropic. The tensor metrics were calculated using DWI with b-value lower than 1750 s/mm². The quantitative anisotropy was extracted as the local connectome fingerprint (LCF, Yeh et al. PLoS Comput Biol 12(11): e1005203) and used in the connectometry analysis.

Connectometry analysis

Diffusion MRI connectometry (Yeh et al. NeuroImage 125 (2016): 162-171) was used to derive the correlational tractography that has QA, MD, AD, and RD correlated with Maze Accuracy and Loop variables. A nonparametric Spearman partial correlation was used to derive the correlation, and the effect of sex, age_scan_years, and repo_status was removed using a multiple regression model. The total number of subjects varied on analysis (See Analyses and Final sample sizes above). A T-score threshold of 2.5 was assigned and tracked using a deterministic fiber tracking algorithm (Yeh et al. PLoS ONE 8(11): e80713, 2013) to obtain correlational tractography. A seeding region was placed at whole brain (39,49,29) . The tracks were filtered by topology-informed pruning (Yeh et al. Neurotherapeutics, 16(1), 52-58, 2019) with 4 iteration(s). A length threshold of 25 voxel distance was used to select tracks. To estimate the false discovery rate, a total of 4000 randomized permutations were applied to the group label to obtain the null distribution of the track length.

Parameters
  • T-threshold = 2.5
  • Length = 25
  • Permutation = 4,000
  • pruning 4
  • non normalized QA

Analyses and Final sample sizes

Exclusions
  • 347 was excluded due to low quality out liar in DSI
Maze Accuracy and Path Efficiency
N
  • All subjects = 82
  • Men = 22
  • Women = 60
  • Stage
    • Pre = 23
    • Peri = 20
    • Post = 17
Loop: Position Error, Degree Error, Angular Error
Rad 3
  • some subjects removed becuase they did not have rad3 score
  • All subjects = 38
  • Men = 14
  • Women = 24
  • Stage
    • Pre = 10
    • Peri = 7
    • Post = 7
Average
  • All subjects = 42
  • Men = 17
  • Women = 25
  • Stage
    • Pre = 23
    • Peri = 20
    • Post = 17

Maze Accuracy

Summary

A total of 82 diffusion MRI scans were included in the connectometry database. For the connectometry analysis, age, sex and repo status were listed as covariates. All subjects displayed positive and negative correlations between tracts with QA and Maze accuracy.Teacts in the fornix with MD and RD displayed positive relationships with Maze accuracy. AD displayed a negative relationship between tracts in the fornix and maze accuracy. All together the results suggest that increased diffusion (Md and RD) are associated with increased performance in scores in midlife participants and these associations are found in regions associated with spatial navigation. When split by sex, Men displayed a negative association between maze performance and a majority of tracts in the corpus callosum with QA. For AD, RD, and MD, men displayed significant positive relationships between performance. Altogether it suggests that better maze accuracy is associated with increased diffusion in midlife men. Women displayed the opposite, tracts in the fornix with QA were positively associated with performance while tracts in the fornix, cingulum, and cerebellum and with AD,RD, and MD were negatively associated with performance. Suggesting that more specific diffusion is associated with better maze accuracy. Next, Menopause stages were analyzed separately. Pre menopausal women displayed both positive and negative correlations with QA while tracts with AD,RD and MD displayed negative relationships. Peri menopausal women displayed positive associations in tracts with QA, MD, RD, and AD and performance. This suggests that in peri menopasual women, maze accuracy is associated with increased diffusion in tracts on the fornix, cerebellum, and cingulum. Post menopausal women displayed both positive and negative associations between acc and QA. Post menopausal women displayed positive and negative assocoations with QA< MD, RD, and AD and maze accuracy. A majority of tracts in the fornix with AD,MD, and RD were positively associated with maze accuracy

DSI output

QA

Summary of results

There were both positive and negative correlations between QA and maze performance when all subjects were included in the analysis. When men were analyzed separately, men displayed more negatively associated correlations between QA and maze performance. Women displayed tracts with predominantly positive correlations between QA and performance. When split by menopause stagge, Pre and post displayed both positive and negative correlations while peri displayed only positive correlations with performance.

All subjects

Positive ( FDR= 0.043228)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 164 57.5732 6.71347 2038
Corpus_Callosum_Forceps_Minor 25 51.92 4.31996 761
Corpus_Callosum_Forceps_Major 22 51.7273 4.37326 777
Cingulum_Parolfactory_R 19 51.6842 3.00273 366
Cingulum_Frontal_Parietal_L 4 52 1.96066 157

Neg ( FDR= 0.122807)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Superior_Longitudinal_Fasciculus2_R 95 56.5053 6.13252 1669
Corpus_Callosum_Forceps_Major 88 54.1364 5.88189 1471
Corpus_Callosum_Tapetum 73 52.5205 6.26296 1618
Cerebellum_L 66 52.8182 5.28801 1160
Cingulum_Frontal_Parietal_L 18 52.8889 2.63768 289
Corpus_Callosum_Forceps_Minor 11 53.4545 2.54066 271
Corpus_Callosum_Body 10 51.4 2.73512 302
Cingulum_Frontal_Parahippocampal_L 5 53.6 1.82363 140
Middle_Cerebellar_Peduncle 5 51.6 2.39777 233

Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze learning accuracy

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze learning accuracy

Glass Brain displaying tracts that had QA positively and negatively correlated with maze learning accuracy

Men

Positive Corrs (FDR = 0.018519)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 38 51.8947 4.63073 874
Corpus_Callosum_Body 2 50 1.34462 71

Neg Corrs (FDR = 0.001161)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 1024 57.0742 14.1861 9021
Middle_Cerebellar_Peduncle 936 58.109 12.1046 6687
Cerebellum_R 340 54.8059 11.0575 5263
Fornix_R 207 56.029 5.50588 1334
Corpus_Callosum_Body 139 53.9712 7.94987 2679
Corpus_Callosum_Tapetum 86 54.4186 6.54345 1830
Corpus_Callosum_Forceps_Major 86 55 6.76172 1975
Inferior_Fronto_Occipital_Fasciculus_L 51 54.2745 4.50209 864
Inferior_Cerebellar_Peduncle_R 36 58.7222 4.55522 957
Inferior_Longitudinal_Fasciculus_L 33 60.1818 4.03615 770

Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze learning accuracy in men

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze learning accuracy in men

Glass Brain displaying tracts that had QA positively and negatively correlated with maze learning accuracy in men

Women

Positive Corrs (FDR = 0.000263)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 454 58.5374 7.88027 2855
Corpus_Callosum_Forceps_Major 198 57.9596 8.40786 3218
Cingulum_Frontal_Parietal_L 169 53.4675 7.14867 2146
Cingulum_Frontal_Parietal_R 151 55.0729 6.58747 1877
Inferior_Fronto_Occipital_Fasciculus_R 149 58.8188 6.25945 1810
Uncinate_Fasciculus_R 132 60.9848 5.96106 1702
Middle_Cerebellar_Peduncle 130 54.0769 6.16263 1613
Corticospinal_Tract_L 98 53.898 7.61388 2454
Cingulum_Parolfactory_R 94 57.9149 5.0565 1163
Middle_Longitudinal_Fasciculus_R 76 51.7368 4.47577 814
Cingulum_Frontal_Parahippocampal_L 51 52.1177 5.31424 1156
Superior_Longitudinal_Fasciculus2_R 49 54.5714 4.16638 744
Superior_Longitudinal_Fasciculus1_L 40 51.5 4.43895 797
Cerebellum_L 40 51.65 4.27395 741
Corticospinal_Tract_R 38 55.8421 3.62712 577
Corpus_Callosum_Forceps_Minor 29 53.7931 4.3542 801
Corticostriatal_Tract_Superior_L 25 51.52 3.79904 584

Neg Corrs (FDR = 0.002809)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 142 53.5493 6.60176 1833
Corpus_Callosum_Forceps_Major 135 54.8593 6.0537 1579
Corpus_Callosum_Body 98 52.4082 5.89418 1430
Corpus_Callosum_Forceps_Minor 76 51.8684 5.68154 1315
Cingulum_Frontal_Parietal_L 75 54.08 4.71935 946
Cingulum_Parolfactory_R 32 55.8125 3.56465 557
Cingulum_Frontal_Parahippocampal_L 24 57.5 2.99467 405
Corticospinal_Tract_L 17 60.4706 3.21204 490
Superior_Longitudinal_Fasciculus2_R 10 58 2.72798 339

Figures

Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze learning accuracy in women

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze learning accuracy in women

Glass Brain displaying tracts that had QA positively and negatively correlated with maze learning accuracy in women

pre

Positive Corrs (FDR = 0.044369)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 187 55.4332 7.16168 2233
Cingulum_Frontal_Parietal_R 92 55.2826 5.08343 1122
Fornix_L 57 55.5789 4.93244 1062
Superior_Longitudinal_Fasciculus1_L 23 51.4783 3.02104 369
Middle_Cerebellar_Peduncle 13 54.4615 3.4258 502
Cingulum_Parolfactory_R 6 62.3333 2.42965 289
Corpus_Callosum_Tapetum 5 54.4 1.71045 125
Corpus_Callosum_Forceps_Major 5 52.8 1.70817 121

Neg Corrs (FDR = 0.011788)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 488 55.5902 8.95216 3499
Corpus_Callosum_Forceps_Major 276 58.6956 6.83875 2156
Cingulum_Frontal_Parietal_L 124 55.4677 5.24401 1198
Corpus_Callosum_Tapetum 111 54.6486 6.39264 1754
Cingulum_Parolfactory_R 75 55.3867 4.2399 782
Corticospinal_Tract_R 52 57.0385 4.4447 885
Corpus_Callosum_Body 42 52.5714 4.32403 772
Cingulum_Frontal_Parahippocampal_L 34 54.7647 3.60182 558
Cingulum_Parolfactory_L 27 52.6667 4.16629 718
Uncinate_Fasciculus_R 25 56.4 3.44922 527
NA NA NA NA NA

Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze learning accuracy in pre-menopausal women

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze learning accuracy in pre-menopausal women

Glass Brain displaying tracts that had QA positively and negatively correlated with maze learning accuracy in pre-menopausal women

peri

Positive Corrs (FDR = 0.000231)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corticospinal_Tract_L 863 57.1031 11.1693 5595
Corticospinal_Tract_R 661 57.1528 9.86907 4372
Corpus_Callosum_Forceps_Minor 444 59.3964 10.6156 5257
Cingulum_Frontal_Parietal_L 143 53.8462 6.18921 1620
Superior_Longitudinal_Fasciculus2_R 106 54.1132 5.56457 1316
Medial_Lemniscus_R 86 55.9302 5.9344 1547
Cingulum_Parolfactory_R 78 60.2051 4.52456 968
Cingulum_Frontal_Parahippocampal_L 44 53.0455 4.53546 857
Corpus_Callosum_Forceps_Major 43 53.7674 4.1148 715
Medial_Lemniscus_L 39 53.8462 4.6869 929

Neg Corrs (FDR = 1.000000)

No Significant Findings

Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze learning accuracy in peri-menopausal women

Glass Brain displaying tracts that had QA positively correlated with maze learning accuracy in peri-menopausal women

post

Positive Corrs (FDR = 0.000418)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 532 57.594 9.34469 3950
Corpus_Callosum_Tapetum 531 55.1224 11.0195 5257
Inferior_Longitudinal_Fasciculus_L 88 58.4545 5.95305 1627
Corticospinal_Tract_R 80 55.925 4.82603 1023
Corticospinal_Tract_L 76 56.2368 5.44395 1309
Inferior_Fronto_Occipital_Fasciculus_L 43 55.3023 4.49092 876
Cingulum_Frontal_Parietal_R 37 52.5405 3.9382 640
Cerebellum_L 29 52.4138 5.18803 1108
Corticopontine_Tract_Occipital_L 26 57.9231 3.6648 611
Corticostriatal_Tract_Posterior_L 25 53.84 4.12924 721

Neg Corrs (FDR = 0.015152)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 32 56.875 5.31736 1263
Cingulum_Parolfactory_R 8 55.75 1.64856 119
Arcuate_Fasciculus_L 3 52 1.41697 82
Corpus_Callosum_Forceps_Major 2 52 1.46789 88

Slice overlay image displaying ROIs with tracts that had QA positively correlated with Maze learning accuracy in post-menopausal women

Slice overlay image displaying ROIs with tracts that had QA negatively correlated with Maze learning accuracy in post-menopausal women

Glass Brain displaying tracts that had QA positively and negatively correlated with maze learning accuracy in post-menopausal women

MD

Summary of results

DSI was run on all subjects, with sex and age listed as covariates. There were positive correlations between MD values in the Fornix (L&R) and performance. Using a sex stratified apporoach we viewed the relationship between white matter and performance in men and women separately. Men, displayed a majortiy of positive correlations between tracts with MD and accuracy. Specifically in regions associated with navigation such as the fornix (L & R). Women, displayed a majortiy of negative correlations between tracts with MD and accuracy. Specifically in regions associated with navigation such as the fornix (L & R), and cerebelllum. We then investigated the relationship of white matter and performance when splitting by menopause stage. Pre menopause women displayed a majortiy of negative correlations between tracts with MD and accuracy in the fornix(L&R) and corpus callosum. Peri menopause women displayed a majority of positive correlations between tracts with MD and accuracy in the fornix(L&R) cerebellum and cingulum. Post Menopause displayed both positive and negative relationships between MD and performance. The majority of tracts with positive correlations were in the fornix, while a majority of the negative correlations were found in tracts in the parietal cortex and cerebellum.

All subjects

Positive Corrs (FDR = 0.124661)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 402 54.3731 7.84916 2631
Fornix_L 272 54.5515 7.16903 2202
Thalamic_Radiation_Superior_L 1 58 1.22179 68

Negative Corrs (FDR = 1.000000)

No significant findings

Slice overlay image displaying ROIs with tracts that had MD positively correlated with Maze learning accuracy

Glass Brain displaying tracts that had MD positively correlated with maze learning accuracy in

Men

Positive Corrs (FDR = 0.012068)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 957 55.3521 9.27769 3742
Fornix_L 473 56.1818 8.32892 3061
Thalamic_Radiation_Superior_L 94 58.2979 5.05501 1170
Superior_Longitudinal_Fasciculus2_R 89 57.3483 5.31629 1273
Arcuate_Fasciculus_R 52 56 5.30758 1239
Thalamic_Radiation_Superior_R 28 55.7857 3.84278 647

Neg Corrs (FDR = 0.075269)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 43 54.3256 4.00388 684

Slice overlay image displaying ROIs with tracts that had MD positively correlated with Maze learning accuracy in men

Glass Brain displaying tracts that had MD positively and negatively correlated with maze learning accuracy in men

Women

Positive Corrs (FDR = 0.071429)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 8 53.5 2.18169 200
Fornix_L 2 52 1.54113 97

Neg Corrs (FDR = 0.061328)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 319 56.9843 7.30304 2387
Cerebellum_L 131 52.8244 5.16782 1108
Fornix_R 126 55.7778 4.78015 1001
Cingulum_Frontal_Parietal_L 39 58.4615 3.37175 522
Thalamic_Radiation_Anterior_L 19 53.4737 2.78608 326
Cerebellum_R 13 53.3846 2.64351 293

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with Maze learning accuracy in women

Glass Brain displaying tracts that had MD negatively correlated with maze learning accuracy in women

pre

Positive Corrs (FDR = 1.000000)

No significant findings

Neg Corrs (FDR = 0.002473)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1210 58.0314 10.1267 4674
Fornix_R 131 54.9924 5.98866 1549
Corpus_Callosum_Forceps_Major 72 55.1389 5.76243 1438
Cerebellum_L 60 53.5 4.57375 879
Thalamic_Radiation_Superior_L 54 58 4.71337 1012
Corpus_Callosum_Tapetum 49 54.898 4.45047 854
Corpus_Callosum_Body 26 52 3.53723 511

Slice overlay image displaying ROIs with tracts that had MD negatively correlated with Maze learning accuracy in pre-menopausal women

Glass Brain displaying tracts that had MD negatively correlated with maze learning accuracy in pre-menopausal women

peri

Positive Corrs (FDR = 0.000106)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1277 59.8168 9.05144 3849
Fornix_R 531 57.7439 7.73441 2713
Cerebellum_L 488 53.291 8.99837 3389
Cerebellum_R 230 55.1304 8.90812 3436
Cingulum_Frontal_Parietal_L 203 56.9458 5.33924 1275
Thalamic_Radiation_Superior_L 121 57.5207 5.92322 1585
Corpus_Callosum_Forceps_Major 82 53.6341 4.98072 1045
Cingulum_Frontal_Parahippocampal_L 42 58.6667 4.14855 793

Neg Corrs (FDR = 0.351351)

No significant findings

Slice overlay image displaying ROIs with tracts that had MD positvely correlated with Maze learning accuracy in peri-menopausal women

Glass Brain displaying tracts that had MD positively correlated with maze learning accuracy in peri-menopausal women

post

Positive Corrs (FDR = 0.000106)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 670 55.5164 8.05206 2827
Fornix_L 348 54.6207 6.29878 1702
Thalamic_Radiation_Superior_L 32 54.0625 3.75909 600
Corpus_Callosum_Tapetum 13 52.1539 3.13274 402

Neg Corrs (FDR = 0.351351)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 256 52.5547 8.66343 3098
Superior_Longitudinal_Fasciculus2_R 246 57.0163 7.45086 2486
Cerebellum_L 203 52.7882 7.8763 2572
Inferior_Longitudinal_Fasciculus_L 159 56.1384 8.01441 2832
Arcuate_Fasciculus_L 109 57.8349 6.97835 2212
Arcuate_Fasciculus_R 82 53.7561 6.83777 1974
Corticostriatal_Tract_Posterior_R 71 53.0704 5.82443 1414
Inferior_Fronto_Occipital_Fasciculus_L 47 56.5106 4.93974 1083
Superior_Longitudinal_Fasciculus2_L 40 54.9 5.27545 1200

Slice overlay image displaying ROIs with tracts that had MD positvely correlated with Maze learning accuracy in post-menopausal women

Glass Brain displaying tracts that had MD positively correlated with maze learning accuracy in pre-menopausal women

combined peri/post

RD

Summary of results

All subjects analyzed, tracts in the fornix were positively associated with acc. In Men, tracts in the fornix were positvely associated with acc. Women showed tracts in the fornix were negatively associated with acc. Pre menopausal women showed a similar findings to women with negative correlations in tracts in the fornix. Peri menopasual women showed results similar to men, with tracts in the fornix positively associated. Post menopausal women displayed positive and negative associations with a majority of positive tracts located in the fornix and negative tracts in the cerebellum.

All subjects

Positive ( FDR= 0.146417 )

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 424 54.2311 7.73295 2547
Fornix_L 159 53.044 6.32374 1666
Thalamic_Radiation_Superior_R 11 52 2.51341 258

Neg ( FDR= 1.000000)

No significant findings

Men

Positive Corrs (FDR = 0.019254)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 1152 55.7396 9.34491 3823
Fornix_L 507 56.2209 8.34911 3078
Thalamic_Radiation_Superior_L 71 59.6338 4.74158 1053
Thalamic_Radiation_Superior_R 20 54.9 3.35728 486

Neg Corrs (FDR = 0.800000)

No Significant Findings

Women

Positive Corrs (FDR = 0.083333)

No Significant Findings

Neg Corrs (FDR = 0.074362)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 280 55.8643 7.1595 2249
Cerebellum_L 94 52.5106 4.81963 958
Fornix_R 64 54.5 4.4352 842
Cingulum_Frontal_Parietal_L 48 59.4167 2.96771 411
Corpus_Callosum_Forceps_Major 28 53.4286 3.45531 501
Thalamic_Radiation_Anterior_L 20 54.1 2.95092 370
Corpus_Callosum_Body 7 50.5714 2.76655 304

pre

Positive Corrs (FDR = 1.000000)

No Significant Findings

Neg Corrs (FDR = 0.010636)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1265 58.4553 10.1983 4775
Fornix_R 193 56.0622 6.8383 2059
Corpus_Callosum_Forceps_Major 64 56.4062 5.0883 1147
Corpus_Callosum_Tapetum 53 55.6226 4.78681 1001
Cerebellum_L 22 52.6364 3.51923 512
Corpus_Callosum_Body 17 51.4118 3.41534 471

peri

Positive Corrs (FDR = 0.000248)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 805 58.9615 7.82847 2838
Fornix_R 322 56.9938 7.13375 2278
Cerebellum_L 288 52.6181 7.71377 2459
Cerebellum_R 94 55.5957 5.86111 1500
Thalamic_Radiation_Superior_L 42 58.8095 4.08032 769
Cingulum_Frontal_Parietal_L 38 57.4211 4.03704 735
Corpus_Callosum_Forceps_Major 28 55.1429 3.38075 495
Cingulum_Frontal_Parahippocampal_L 21 62 3.37298 554

Neg Corrs (FDR = 0.000000)

No Significant Findings

post

Positive Corrs (FDR = 0.000777)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 606 55.2706 7.80881 2647
Fornix_L 262 54.2519 5.83353 1450
Thalamic_Radiation_Superior_L 21 55.5238 3.23369 456
Corpus_Callosum_Tapetum 14 52.7143 3.32964 459

Neg Corrs (FDR = 0.040343)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 228 52.7895 8.23841 2814
Cerebellum_L 171 52.7251 7.92226 2599
Corticostriatal_Tract_Posterior_R 99 54.0404 6.24446 1655
Inferior_Longitudinal_Fasciculus_L 69 55.2464 6.37245 1762
Corpus_Callosum_Forceps_Major 56 53.8929 4.97588 1048
Superior_Longitudinal_Fasciculus2_R 42 54.0476 4.8122 983
Frontal_Aslant_Tract_L 35 59.7714 4.38826 904
Middle_Longitudinal_Fasciculus_R 19 53.7895 4.37874 810
Arcuate_Fasciculus_R 18 52.7778 3.54186 520
Inferior_Fronto_Occipital_Fasciculus_L 17 55.5294 3.99483 696
Corpus_Callosum_Tapetum 10 57.6 3.31786 498
Inferior_Fronto_Occipital_Fasciculus_R 9 50.6667 2.80457 313

peri post combination

Positive Corrs (FDR = 0.000994)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 369 55.0406 6.07426 1595
Fornix_R 140 55.4857 6.28062 1719

Neg Corrs (FDR = 0.009259)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Positive Correlation 510 55.1529 8.82166 3371
Cerebellum_R 55 52.2182 4.94532 1003

Loop Position Error Rad3

QA

Summary of results

QA values in several tracts were negatively correlated with Loop Position Error performance in a circle with a 3 m radius. When men and women were analyzed separately, there were different relationships observed. The majority of tracts in men were positively correlated with Position Error and QA values.Suggesting that better QA and white matter integrity is associated with increased Position error. The majority of tracts in women were negatively correlated with QA values and Position error, with a few that were positive. This suggests that in women, white matter integrity is associated with lower position error scores. When splitting by meno pause stage, Pre menopausal women displayed both negative and positive relationships between QA and position error. Peri menopausal women displayed negative correlations between QA and position error. .

All subjects

Positive Corrs (FDR = 0.077333)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 182 53.8249 8.31103 2920
Cerebellum_L 49 52.8296 4.37448 794

Neg Corrs (FDR = 0.001964)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corticospinal_Tract_R 490 55.2333 9.66114 4049
Arcuate_Fasciculus_R 258 52.8135 5.58318 1293
Medial_Lemniscus_R 142 56.1227 6.02296 1599
Corpus_Callosum_Tapetum 82 53.152 6.83284 1949
Dentatorubrothalamic_Tract_R 24 52.5069 4.30703 765
Arcuate_Fasciculus_L 19 53.5862 3.42257 493

Men

Positive Corrs (FDR= 0.074986)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 612 56.9446 10.2611 4709
Corpus_Callosum_Forceps_Minor 367 58.0118 10.7864 5301
Corticospinal_Tract_R 201 58.926 6.683 2067
Cerebellum_R 168 52.7355 8.24409 2815
Inferior_Fronto_Occipital_Fasciculus_R 106 57.7104 6.43346 1876
Arcuate_Fasciculus_L 68 55.3639 6.09813 1617
Vermis 54 53.9354 5.07493 1091
Corpus_Callosum_Tapetum 50 54.9697 6.20826 1664
Superior_Longitudinal_Fasciculus2_R 49 55.6835 5.29033 1224
Medial_Lemniscus_R 49 57.4788 5.34352 1289
Corpus_Callosum_Body 48 55.7614 6.14362 1653
Corticostriatal_Tract_Superior_R 42 55.0071 4.98362 1073
Middle_Cerebellar_Peduncle 30 68.0103 3.33754 595
Corticopontine_Tract_Parietal_R 28 60.1481 4.64214 1018
Corticopontine_Tract_Parietal_L 22 57.0879 4.53962 924
Arcuate_Fasciculus_R 20 53.9119 4.30574 785
Thalamic_Radiation_Posterior_L 20 53.9063 3.65308 565
Corticostriatal_Tract_Posterior_L 19 64.4431 4.32784 948
Cingulum_Frontal_Parietal_L 17 54.4706 1.90957 156
Superior_Longitudinal_Fasciculus3_R 16 56.3938 3.86021 660
Dentatorubrothalamic_Tract_R 12 53.0211 3.0954 399
Thalamic_Radiation_Anterior_R 11 55.113 2.84762 351
Inferior_Longitudinal_Fasciculus_R 10 55.0113 2.93427 372
Parietal_Aslant_Tract_L 10 55.818 2.24525 221

Neg Corrs (FDR = 0.316832)

Not significant

Women

Positive Corrs (FDR = 0.076923)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 42 53.7147 4.57498 883

Neg Corrs (FDR = 0.000559)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corticospinal_Tract_R 474 55.9604 9.02897 3583
Medial_Lemniscus_R 198 57.2198 6.17031 1711
Arcuate_Fasciculus_R 137 53.5168 5.07838 1084
Corpus_Callosum_Tapetum 64 55.5103 5.31802 1233
Cingulum_Frontal_Parietal_L 53 54.2412 4.02161 689
Inferior_Longitudinal_Fasciculus_R 47 56.3877 4.46016 881
Corticospinal_Tract_L 37 56.7692 4.82268 1037
Corticostriatal_Tract_Superior_R 24 52.1719 4.33211 769
Dentatorubrothalamic_Tract_R 24 52.8405 4.08343 692
Inferior_Fronto_Occipital_Fasciculus_L 20 52.6101 3.78513 592
Extreme_Capsule_L 14 52.1561 3.02161 374

pre

Positive Corrs (FDR = 0.035113)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 467 60.7675 10.4772 5239
Corpus_Callosum_Tapetum 369 54.9856 10.7794 5018
Corpus_Callosum_Body 332 59.1764 9.13332 3877
Cerebellum_L 145 55.0137 7.3497 2334
Corpus_Callosum_Forceps_Minor 130 57.4251 6.61573 1974
Fornix_L 63 62.5827 4.14135 843
Fornix_R 42 54.1492 3.35954 480
Arcuate_Fasciculus_L 25 54.8817 2.69041 312
Thalamic_Radiation_Posterior_L 25 54.9735 4.04372 706
Inferior_Longitudinal_Fasciculus_L 19 62.8484 3.86142 736
Inferior_Fronto_Occipital_Fasciculus_L 15 54.2737 2.85726 348
Corticostriatal_Tract_Posterior_L 13 53.6994 3.17069 424
Cingulum_Frontal_Parietal_R 10 61.8106 2.68124 349
Inferior_Longitudinal_Fasciculus_R 10 54.0064 3.01275 385

Neg Corrs (FDR = 0.009547)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Inferior_Fronto_Occipital_Fasciculus_R 334 63.0291 8.13498 3276
Corticospinal_Tract_L 227 56.7152 10.3753 4795
Inferior_Fronto_Occipital_Fasciculus_L 221 55.8831 6.75546 2003
Corticospinal_Tract_R 213 58.3563 8.54936 3350
Cerebellum_L 210 55.8243 7.82411 2684
Middle_Cerebellar_Peduncle 174 55.735 8.04762 2835
Cingulum_Frontal_Parietal_L 172 55.3882 5.88382 1506
Corpus_Callosum_Tapetum 162 59.8389 7.27886 2490
Inferior_Longitudinal_Fasciculus_R 142 57.1087 5.69359 1454
Medial_Lemniscus_L 108 57.3986 6.87698 2132
Corticostriatal_Tract_Superior_L 92 56.2078 7.49821 2482
Arcuate_Fasciculus_L 88 58.4879 6.04751 1680
Cingulum_Parolfactory_R 78 60.8837 4.0928 801
Arcuate_Fasciculus_R 75 62.3341 6.6592 2171
Cingulum_Frontal_Parietal_R 69 56.2722 5.42559 1301
Medial_Lemniscus_R 67 55.8288 5.76046 1455
Dentatorubrothalamic_Tract_L 54 55.127 5.80697 1460
Vermis 52 53.4712 4.60352 890
Corticopontine_Tract_Parietal_L 51 63.3048 4.43966 980
Superior_Longitudinal_Fasciculus2_R 43 58.344 4.97027 1132
Dentatorubrothalamic_Tract_R 41 55.759 5.37456 1265
Cingulum_Frontal_Parahippocampal_L 38 53.5918 4.17878 735
Superior_Longitudinal_Fasciculus2_L 37 54.8211 5.11161 1125
Corpus_Callosum_Body 30 53.0169 4.53403 856
Uncinate_Fasciculus_R 19 56.953 2.89543 375
Cingulum_Frontal_Parahippocampal_R 15 54.9303 2.73622 323
Extreme_Capsule_L 15 58.9499 3.48093 561
Corticopontine_Tract_Parietal_R 13 60.4696 3.29299 515
Corpus_Callosum_Forceps_Major 13 57.3873 2.82224 359
Cingulum_Parolfactory_L 12 54.3225 2.62952 295
Corticostriatal_Tract_Posterior_R 11 54.5534 3.39209 493

peri

Positive Corrs (FDR = 0.331167)

No Significant Findings

Neg Corrs (FDR = 0.097716)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 389 65.318 16.4872 13945
Cerebellum_L 282 55.5988 14.5363 9227
Corpus_Callosum_Tapetum 227 63.9398 12.609 7984
Cerebellum_R 216 54.6297 13.8573 8239
Corpus_Callosum_Forceps_Major 215 60.7879 11.9537 6822
Inferior_Fronto_Occipital_Fasciculus_R 200 63.1616 10.8928 5886
Middle_Cerebellar_Peduncle 193 61.3758 12.0195 6964
Arcuate_Fasciculus_R 183 67.7836 10.0947 5425
Superior_Longitudinal_Fasciculus2_R 176 64.0562 10.4205 5463
Corticospinal_Tract_R 144 64.9148 9.72516 4822
Arcuate_Fasciculus_L 136 58.7007 10.6294 5209
Cingulum_Frontal_Parietal_R 118 66.8574 7.7747 3174
Corticostriatal_Tract_Posterior_R 113 65.6592 9.2034 4368
Inferior_Longitudinal_Fasciculus_R 100 60.9458 9.73786 4539
Inferior_Longitudinal_Fasciculus_L 95 62.434 8.71113 3721
Medial_Lemniscus_R 85 63.7718 7.71216 2979
Inferior_Fronto_Occipital_Fasciculus_L 84 63.6238 8.49372 3605
Dentatorubrothalamic_Tract_R 82 59.7679 9.52074 4255
Superior_Longitudinal_Fasciculus2_L 77 60.1905 8.63884 3528
Corticostriatal_Tract_Posterior_L 73 62.1426 8.586 3598
Frontal_Aslant_Tract_L 69 61.3461 8.16996 3216
Corticospinal_Tract_L 65 62.0028 7.61655 2825
Dentatorubrothalamic_Tract_L 64 58.3524 8.51512 3323
Medial_Lemniscus_L 63 58.0775 6.64313 2013
Corticostriatal_Tract_Superior_L 61 56.2701 7.97103 2808
Cingulum_Frontal_Parietal_L 59 60.5532 6.59738 2070
Thalamic_Radiation_Posterior_R 54 60.9672 6.63817 2110
Corticopontine_Tract_Parietal_R 53 61.7509 6.79758 2241
Vermis 53 55.7069 6.6417 1930
Corpus_Callosum_Forceps_Minor 52 56.8889 7.31681 2392
Cingulum_Parahippocampal_Parietal_R 39 56.8344 5.50552 1353
Corticostriatal_Tract_Superior_R 38 61.1728 6.64895 2124
Corticopontine_Tract_Parietal_L 32 66.2582 5.7957 1748
Anterior_Commissure 32 64.3199 5.47813 1516
Superior_Longitudinal_Fasciculus1_R 31 66.141 5.22281 1417
Extreme_Capsule_R 29 62.2185 5.25219 1348
Optic_Radiation_L 27 55.3384 4.67031 948
Cingulum_Parolfactory_R 25 66.9676 4.09735 883
Extreme_Capsule_L 25 58.8064 4.88687 1103
Thalamic_Radiation_Anterior_R 25 63.768 4.98384 1244
Fornix_R 25 67.1349 3.29078 571
Parietal_Aslant_Tract_L 24 57.1033 5.18774 1207
Superior_Longitudinal_Fasciculus3_R 24 61.1716 4.94958 1177
Thalamic_Radiation_Posterior_L 21 57.3387 5.32508 1277
Reticular_Tract_R 20 62.9166 5.0255 1248
Middle_Longitudinal_Fasciculus_R 18 59.0135 4.55819 963
Corticopontine_Tract_Frontal_R 15 60.8106 4.70438 1057
Parietal_Aslant_Tract_R 14 55.2972 3.7508 611
Superior_Longitudinal_Fasciculus3_L 14 58.2923 4.07969 762
Thalamic_Radiation_Superior_R 14 61.4203 4.48189 969
Frontal_Aslant_Tract_R 12 53.3226 3.93357 648
Cingulum_Parolfactory_L 11 59.4667 2.48321 288
Middle_Longitudinal_Fasciculus_L 11 55.8305 3.80245 634
Corticopontine_Tract_Occipital_R 11 66.9093 2.93927 454
Reticular_Tract_L 10 60.4207 3.78266 679

post

  • No significant results

Peri + Post

Positive Corrs (FDR = 0.058838)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 610 58.0052 11.3173 5835
Corpus_Callosum_Body 567 60.2729 15.4467 11295
Corpus_Callosum_Forceps_Major 216 60.1026 8.37506 3311
Corpus_Callosum_Tapetum 186 53.8132 8.40112 2983
Middle_Cerebellar_Peduncle 168 57.4141 8.9189 3587
Cingulum_Frontal_Parietal_R 120 59.2436 6.42202 1919
Inferior_Fronto_Occipital_Fasciculus_R 73 56.9139 5.40113 1304
Uncinate_Fasciculus_R 60 58.2733 5.3826 1326
Corticospinal_Tract_R 54 63.2633 6.07711 1835
Cingulum_Frontal_Parietal_L 45 56.012 4.16463 763
Cingulum_Parolfactory_R 44 58.9173 4.20446 818
Cingulum_Parolfactory_L 42 53.9153 2.67056 302
Cerebellum_L 28 53.9362 3.75092 596
Medial_Lemniscus_L 21 60.9571 3.81283 696
Cingulum_Frontal_Parahippocampal_R 20 62.7993 3.66912 664
Dentatorubrothalamic_Tract_R 19 59.3764 4.56073 970
Corticostriatal_Tract_Superior_L 17 55.7736 4.52014 895
Frontal_Aslant_Tract_L 14 65.7165 3.05274 481
Corticospinal_Tract_L 13 53.3896 3.61837 549
Superior_Longitudinal_Fasciculus2_R 10 57.0185 2.62254 308
Thalamic_Radiation_Anterior_R 10 57.8096 3.12361 443

Neg Corrs (FDR = 0.103819)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 747 65.6606 13.9656 10058
Cerebellum_R 676 56.1446 15.0471 9984
Corpus_Callosum_Forceps_Major 452 68.9254 11.2899 6900
Corpus_Callosum_Body 430 65.3869 13.335 9132
Corpus_Callosum_Tapetum 284 59.2157 11.2852 5923
Inferior_Fronto_Occipital_Fasciculus_L 259 63.332 8.75312 3811
Corticospinal_Tract_R 241 62.5639 7.8772 3049
Arcuate_Fasciculus_L 148 54.4935 8.06814 2786
Inferior_Longitudinal_Fasciculus_L 102 61.362 6.9487 2327
Cerebellum_L 84 54.9857 6.68685 1931
Medial_Lemniscus_R 83 57.2871 5.75659 1491
Superior_Longitudinal_Fasciculus2_R 76 58.0129 4.85958 1076
Cingulum_Frontal_Parietal_R 71 59.3032 5.50791 1413
Corticostriatal_Tract_Superior_R 49 54.6997 5.53676 1317
Thalamic_Radiation_Posterior_L 47 56.5159 5.20815 1204
Corticostriatal_Tract_Posterior_L 43 59.5929 5.99118 1680
Inferior_Fronto_Occipital_Fasciculus_R 41 55.8663 4.90583 1056
Corticostriatal_Tract_Posterior_R 32 56.9503 4.7519 1010
Thalamic_Radiation_Posterior_R 32 54.262 5.25081 1175
Middle_Longitudinal_Fasciculus_R 26 55.2224 4.88503 1035
Extreme_Capsule_R 25 54.7369 4.10945 726
Corticostriatal_Tract_Superior_L 25 54.1743 4.16755 739
Arcuate_Fasciculus_R 24 57.0949 4.36911 856
Corticostriatal_Tract_Anterior_L 22 55.0136 3.29463 469
Middle_Longitudinal_Fasciculus_L 21 56.1993 3.95952 692
Thalamic_Radiation_Anterior_L 20 60.4115 3.61777 621
Cingulum_Frontal_Parietal_L 19 60.1043 3.72213 654
Corticospinal_Tract_L 16 56.143 3.9299 681
Medial_Lemniscus_L 16 56.2595 3.44039 523
Cingulum_Parolfactory_L 14 58.4268 2.9891 410
Inferior_Longitudinal_Fasciculus_R 13 55.2469 3.79526 625
Corticopontine_Tract_Parietal_R 13 58.9449 3.62694 609
Fornix_L 12 52.4974 3.31829 454
Middle_Cerebellar_Peduncle 11 63.6419 3.29597 543

MD

Summary of results

When analyzing all subjects, tracts in fornix and thalamix radion were negatively associated with PE scores. In men, tracts in the fornix were positively associated with loop PE scores. In women, and all menopause stages, tracts were negatively associated with MD and loop PE scores. Increased scores signify poor performance.

All subjects

Positive Corrs (FDR = 1.000000)

No significant results

Neg Corrs (FDR = 0.000616)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 394 56.0872 7.10863 2226
Fornix_L 312 55.1057 7.63814 2525
Thalamic_Radiation_Superior_L 12 52.0137 2.7054 299

Men

Positive Corrs (FDR = 0.058621)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1288 59.2327 9.09596 3849
Fornix_R 192 57.1619 6.21299 1733
Thalamic_Radiation_Superior_L 96 57.3998 5.80086 1517
Corpus_Callosum_Forceps_Major 18 53.905 3.51473 523

Neg Corrs (FDR = 1.000000)

No significant results

Women

Positive Corrs(FDR = 1.000000)

No Significant Results

Neg Corrs (FDR = 0.000443)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 634 55.6436 8.92995 3485
Fornix_R 253 54.9831 6.34586 1739
Corpus_Callosum_Tapetum 74 58.1445 5.65234 1459
Thalamic_Radiation_Superior_L 64 53.57 5.26208 1165
Corpus_Callosum_Body 49 57.8469 4.22499 811
Optic_Radiation_L 22 56.3585 3.12043 431
Cingulum_Frontal_Parietal_L 13 54.7812 1.5015 97
Corpus_Callosum_Forceps_Major 11 52.5547 2.3962 237

pre

Positive Corrs (FDR = 1.000000)

No Significant Results

Neg Corrs (FDR = 0.044429)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1819 60.5114 11.666 6468
Fornix_R 1031 58.0808 9.61823 4220
Corpus_Callosum_Tapetum 303 61.3149 11.7061 6599
Corpus_Callosum_Forceps_Major 215 62.6589 8.4128 3483
Corpus_Callosum_Body 197 61.8598 11.1996 6094
Cerebellum_R 176 53.9868 7.53284 2406
Thalamic_Radiation_Superior_L 101 53.6068 6.3823 1715
Optic_Radiation_L 56 56.2564 5.17442 1183
Corticostriatal_Tract_Posterior_R 46 55.9619 6.62312 1928
Thalamic_Radiation_Superior_R 27 55.2688 3.93752 673
Cingulum_Frontal_Parietal_L 24 54.2634 3.13177 418
Inferior_Fronto_Occipital_Fasciculus_R 24 57.9236 4.72579 1016
Thalamic_Radiation_Posterior_R 24 55.341 4.86563 1029
Medial_Lemniscus_R 24 53.8532 4.72178 943
Cingulum_Parahippocampal_Parietal_R 22 56.0942 3.5843 566
Cingulum_Frontal_Parietal_R 17 55.533 3.77941 623
Inferior_Fronto_Occipital_Fasciculus_L 15 60.6624 3.42532 559
Middle_Cerebellar_Peduncle 15 54.2922 2.74371 321
Anterior_Commissure 14 65.1589 2.73212 382
Arcuate_Fasciculus_L 13 51.2463 2.84599 326
Middle_Longitudinal_Fasciculus_R 12 70.1754 3.53054 687
Inferior_Longitudinal_Fasciculus_R 11 56.3833 3.54974 558
Arcuate_Fasciculus_R 10 56.0151 3.272 471
Superior_Longitudinal_Fasciculus1_L 10 53.029 2.33459 227
Thalamic_Radiation_Posterior_L 10 76.8091 3.09537 578

peri

Positive Corrs(FDR = 1.000000)

No Significant Results

Neg Corrs (FDR = 0.017058)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 137 61.5622 9.16124 4058
Corpus_Callosum_Forceps_Major 117 61.5106 10.1612 4988
Corpus_Callosum_Body 91 63.0188 8.15053 3288
Cerebellum_R 88 54.6434 8.43845 3056
Corticostriatal_Tract_Posterior_R 70 55.4353 7.45229 2418
Fornix_L 70 62.0394 6.31315 1942
Inferior_Longitudinal_Fasciculus_R 61 63.2245 7.60509 2872
Cerebellum_L 51 53.3808 6.54144 1794
Corpus_Callosum_Forceps_Minor 38 59.3224 6.33021 1867
Arcuate_Fasciculus_R 30 58.5445 5.08728 1190
Inferior_Fronto_Occipital_Fasciculus_R 24 58.0717 4.95101 1118
Arcuate_Fasciculus_L 23 56.006 4.44475 869
Inferior_Fronto_Occipital_Fasciculus_L 23 60.4446 5.17427 1271
Inferior_Longitudinal_Fasciculus_L 19 60.4344 4.12335 807
Dentatorubrothalamic_Tract_L 19 55.3776 4.51596 887
Fornix_R 19 59.5998 3.19556 478
Middle_Cerebellar_Peduncle 14 63.7231 3.72648 695
Thalamic_Radiation_Superior_L 13 56.9342 3.70253 613
Corticostriatal_Tract_Posterior_L 12 55.5128 3.57105 556
Dentatorubrothalamic_Tract_R 12 59.83 3.53439 587
Optic_Radiation_L 12 54.9985 3.67064 582
Anterior_Commissure 12 57.3476 3.67409 608
Superior_Longitudinal_Fasciculus2_L 11 58.5526 3.40124 532
Superior_Longitudinal_Fasciculus2_R 11 55.6393 3.60527 568
Cingulum_Frontal_Parietal_L 10 61.2007 3.22524 500
Superior_Longitudinal_Fasciculus1_R 10 57.2059 2.28701 235
Corticospinal_Tract_L 10 53.4043 3.26818 448
Thalamic_Radiation_Posterior_R 10 52.5978 3.59872 535
Reticular_Tract_L 10 62.4156 2.8601 401

post

Positive Corrs (FDR = 1.000000)

No Significant Results

Neg Corrs (FDR = 0.064410)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Arcuate_Fasciculus_L 156 61.1147 9.05199 3933
Corpus_Callosum_Forceps_Major 140 60.0388 8.63994 3520
Cerebellum_R 139 54.6339 10.6622 4878
Inferior_Longitudinal_Fasciculus_L 116 62.8715 8.9405 3947
Cerebellum_L 115 54.0622 9.27667 3654
Fornix_L 89 54.4819 6.04764 1565
Corpus_Callosum_Tapetum 81 59.2701 8.44513 3320
Inferior_Longitudinal_Fasciculus_R 77 58.9461 8.47213 3323
Superior_Longitudinal_Fasciculus2_L 68 58.1598 7.05413 2273
Corpus_Callosum_Body 63 57.3084 8.31507 3112
Inferior_Fronto_Occipital_Fasciculus_R 45 56.3659 6.85454 2080
Corpus_Callosum_Forceps_Minor 44 60.1086 6.44011 1958
Corticostriatal_Tract_Posterior_L 39 63.8606 5.85262 1718
Corticostriatal_Tract_Posterior_R 33 56.7263 5.57555 1385
Thalamic_Radiation_Superior_L 30 59.4745 4.03364 760
Thalamic_Radiation_Posterior_L 25 55.5278 5.47441 1307
Middle_Cerebellar_Peduncle 24 60.1675 5.10806 1233
Superior_Longitudinal_Fasciculus2_R 23 57.9138 5.01726 1145
Frontal_Aslant_Tract_L 21 63.5285 4.41825 974
Fornix_R 19 56.2117 3.07702 418
Inferior_Fronto_Occipital_Fasciculus_L 15 58.4104 4.4782 920
Parietal_Aslant_Tract_L 14 59.4525 2.82255 372
Dentatorubrothalamic_Tract_L 14 56.1464 3.82153 644
Medial_Lemniscus_R 14 61.4312 4.23907 867
Arcuate_Fasciculus_R 13 54.7848 3.80818 624
Corticostriatal_Tract_Anterior_L 13 55.86 3.83726 646
Corticostriatal_Tract_Anterior_R 13 54.008 4.20771 751
Corticostriatal_Tract_Superior_L 11 56.0279 3.5128 543

Peri + Post

Positive Corrs (FDR = 1.000000)

No Significant Results

Neg Corrs (FDR = 0.161324)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 400 58.6692 8.11042 3031
Corpus_Callosum_Tapetum 383 59.2374 10.4802 5110
Cerebellum_R 97 53.4518 6.60958 1834
Corpus_Callosum_Forceps_Major 54 60.3021 5.40771 1385
Corpus_Callosum_Body 50 57.8098 5.57465 1411
Thalamic_Radiation_Superior_L 48 57.2993 4.26601 819
Fornix_R 25 51.9201 3.55033 514
Inferior_Fronto_Occipital_Fasciculus_L 15 56.6684 3.31466 489
Cerebellum_L 14 50.7299 3.14464 394
Cingulum_Frontal_Parietal_L 13 56.4625 2.41671 259
Inferior_Longitudinal_Fasciculus_R 13 58.1644 3.03936 422
Middle_Cerebellar_Peduncle 13 54.3025 2.23478 213

AD

Summary of results

The majority of tracts with AD were negatively correlated with position error when looking at all subjects. Men displayed positive correlations. women and all menopause groups displayed negative correlations with PE.

All subjects

Positive Corrs (FDR = 0.010526)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 28 51.5934 3.83514 596
Cerebellum_L 20 51.2035 3.46201 482

Neg Corrs (FDR = 0.000260)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 743 56.3102 7.84379 2721
Fornix_L 618 55.0674 8.52336 3142
Corpus_Callosum_Forceps_Major 38 56.5343 3.50024 544
Cingulum_Frontal_Parietal_L 36 57.7278 3.36373 513
Corpus_Callosum_Tapetum 29 54.7608 3.74748 604
Thalamic_Radiation_Anterior_L 12 52.6622 2.31154 221

Men

Positive Corrs (FDR = 0.064215)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1006 56.7049 9.47945 4002
Fornix_R 205 55.317 6.50604 1839
Thalamic_Radiation_Superior_L 81 56.2249 5.10538 1151
Cerebellum_L 32 52.7549 3.94857 646
Corpus_Callosum_Forceps_Major 18 53.7799 3.23487 442

Neg Corrs (FDR = 0.111111)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Inferior_Longitudinal_Fasciculus_R 17 52.9505 3.38317 476

Women

Positive Corrs (FDR = 1.000000)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 3 51.3333 1.53503 95

Neg Corrs (FDR = 0.000332)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1199 56.0989 9.56854 4034
Fornix_R 326 55.2793 6.73608 1970
Corpus_Callosum_Tapetum 256 57.7053 8.64225 3385
Thalamic_Radiation_Superior_L 174 53.4019 7.49805 2358
Cingulum_Frontal_Parietal_L 94 59.6684 4.37501 897
Optic_Radiation_L 50 55.5326 3.86935 653
Inferior_Fronto_Occipital_Fasciculus_L 30 54.2785 3.68218 578
Thalamic_Radiation_Anterior_L 18 51.9984 2.49879 255
Corpus_Callosum_Forceps_Major 12 53.8436 2.49382 263
Superior_Longitudinal_Fasciculus1_L 10 55.0248 2.54084 279

pre

Positive Corrs (FDR = 1.000000)

No significant results

Neg Corrs (FDR = 0.047725)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1651 59.6786 11.6321 6342
Fornix_R 1228 58.3895 10.1913 4763
Corpus_Callosum_Tapetum 415 60.3476 13.9473 9220
Corpus_Callosum_Forceps_Major 363 61.3873 10.3523 5167
Cerebellum_R 292 54.0498 8.32207 2940
Thalamic_Radiation_Superior_L 169 54.481 7.57766 2457
Corpus_Callosum_Body 161 58.0473 11.082 5599
Optic_Radiation_L 145 56.2027 7.68947 2610
Corticostriatal_Tract_Posterior_R 61 57.944 6.70671 2047
Thalamic_Radiation_Superior_R 53 55.2126 4.8949 1039
Thalamic_Radiation_Posterior_R 47 57.913 5.85263 1558
Corticospinal_Tract_R 46 54.7416 4.8803 1024
Arcuate_Fasciculus_R 41 56.1059 4.56677 919
Cingulum_Frontal_Parietal_L 41 55.8155 4.86605 1038
Corticospinal_Tract_L 40 55.5035 4.95898 1072
Dentatorubrothalamic_Tract_R 39 57.0285 4.76742 1018
Corticostriatal_Tract_Posterior_L 30 55.348 4.0726 721
Inferior_Fronto_Occipital_Fasciculus_L 27 55.7882 4.71722 975
Anterior_Commissure 25 57.5349 4.24426 814
Optic_Radiation_R 20 53.3041 2.80332 329
Superior_Longitudinal_Fasciculus1_L 19 58.8473 3.02883 424
Inferior_Fronto_Occipital_Fasciculus_R 17 58.0195 3.93892 707
Corticopontine_Tract_Occipital_R 17 60.237 3.39096 544
Inferior_Longitudinal_Fasciculus_L 16 55.8945 4.03574 715
Cingulum_Frontal_Parahippocampal_L 14 70.2952 2.68156 397
Inferior_Longitudinal_Fasciculus_R 11 60.2174 3.40706 549

peri

Positive Corrs (FDR = 1.000000)

No significant results

Neg Corrs (FDR = 0.008203)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 199 67.721 10.4245 5780
Cerebellum_R 109 54.3733 8.86357 3355
Corpus_Callosum_Forceps_Major 85 62.3891 8.03561 3164
Cerebellum_L 61 53.9053 6.63711 1865
Fornix_L 58 60.2531 5.90125 1648
Corpus_Callosum_Body 46 59.6128 6.90605 2233
Inferior_Longitudinal_Fasciculus_L 39 56.3134 5.60605 1390
Arcuate_Fasciculus_R 35 62.4165 5.195 1323
Middle_Cerebellar_Peduncle 34 55.1787 5.50639 1314
Corticostriatal_Tract_Posterior_R 31 58.4015 6.2225 1776
Inferior_Fronto_Occipital_Fasciculus_R 28 56.7136 5.87992 1540
Dentatorubrothalamic_Tract_R 28 60.7262 5.58558 1488
Corticospinal_Tract_R 26 61.4727 4.40303 936
Optic_Radiation_L 24 58.6673 4.87043 1093
Inferior_Longitudinal_Fasciculus_R 22 58.8292 5.51045 1403
Inferior_Fronto_Occipital_Fasciculus_L 20 58.2011 4.70056 1010
Corticospinal_Tract_L 20 58.912 4.23027 828
Dentatorubrothalamic_Tract_L 20 56.2169 4.45932 878
Fornix_R 20 70.5088 3.38092 633
Corticopontine_Tract_Parietal_L 18 62.2331 3.44178 579
Arcuate_Fasciculus_L 16 60.1427 4.14867 813
Cingulum_Parolfactory_R 16 63.26 3.63641 657
Superior_Longitudinal_Fasciculus2_L 16 56.0159 3.64027 583
Corticostriatal_Tract_Posterior_L 15 55.5925 4.12239 742
Thalamic_Radiation_Posterior_L 15 57.475 4.24907 815
Medial_Lemniscus_R 15 60.8077 3.67783 646
Thalamic_Radiation_Posterior_R 14 58.3029 4.05785 754
Thalamic_Radiation_Anterior_R 13 52.7813 3.43103 488
Middle_Longitudinal_Fasciculus_R 11 53.6439 3.68784 573
Anterior_Commissure 11 56.5676 3.30401 485
Corpus_Callosum_Forceps_Minor 11 58.9136 3.57993 593
Corticopontine_Tract_Parietal_R 10 55.9984 3.18088 445

post

Positive Corrs (FDR = 1.000000)

No significant results

Neg Corrs (FDR = 0.059079)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 124 55.721 9.39889 3866
Cerebellum_L 108 54.0504 8.86214 3334
Corpus_Callosum_Forceps_Major 50 57.6534 5.88271 1567
Corpus_Callosum_Tapetum 42 56.5758 6.64661 1963
Fornix_L 40 60.4076 4.93188 1154
Inferior_Fronto_Occipital_Fasciculus_R 27 52.3079 5.15564 1092
Thalamic_Radiation_Superior_L 26 60.0895 3.3353 525
Inferior_Longitudinal_Fasciculus_L 15 56.6874 4.23628 799
Fornix_R 15 58.3923 3.11849 446
Arcuate_Fasciculus_L 13 54.4679 3.64063 567
Corpus_Callosum_Body 13 55.3812 4.07702 723
Middle_Cerebellar_Peduncle 13 57.2322 3.7556 634
Corticostriatal_Tract_Posterior_R 12 52.5135 3.86465 616
Cingulum_Parolfactory_R 11 55.841 2.67574 314
Corticostriatal_Tract_Superior_R 10 54.2115 2.59175 286

Peri + Post

Positive Corrs (FDR = 0.652842)

No significant results

Neg Corrs (FDR = 0.063222)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 313 58.1794 9.83294 4418
Fornix_L 175 57.1635 6.5735 1940
Cerebellum_R 135 53.6672 7.44612 2337
Corpus_Callosum_Forceps_Major 95 56.9948 6.50813 1896
Corpus_Callosum_Body 88 54.331 5.12776 1122
Thalamic_Radiation_Superior_L 31 56.8448 4.3143 831
Fornix_R 30 54.0027 3.66593 570
Inferior_Fronto_Occipital_Fasciculus_L 22 53.1017 3.72598 579
Cingulum_Frontal_Parietal_L 11 56.3657 2.13611 202

RD

Summary of results

Tracts with RD displayed negtive correlations with PE. In men, this was opposite with men displaying positive correlations. Women, and those in the peri and post stages displayed negative correlations. Those in the pre and peri+post group displayed positive and negative correlations.

All subjects

Positive Corrs (FDR = 0.625000)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 12 54.1782 2.82256 339

Neg Corrs (FDR = 0.000639)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 429 55.5107 6.94688 2104
Fornix_L 293 55.8203 7.44036 2427

Men

Positive Corrs (FDR = 0.057317)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1339 59.5003 9.2147 3968
Fornix_R 186 56.0247 6.09011 1632
Thalamic_Radiation_Superior_L 97 56.4795 5.6199 1401
Corpus_Callosum_Forceps_Major 25 55.5253 3.91379 668

Neg Corrs Not significant (1.000000)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 11 54.3654 1.83643 144

Women

Positive Corrs (FDR = 1.000000)

No significant results

Neg Corrs (FDR = 0.002117)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1042 56.0036 10.0301 4425
Fornix_R 577 55.6089 7.64404 2552
Corpus_Callosum_Body 121 56.4221 6.90199 2111
Corpus_Callosum_Tapetum 96 57.9274 5.95614 1614
Thalamic_Radiation_Superior_L 90 55.0884 5.56723 1341
Cingulum_Frontal_Parietal_L 14 56.2972 2.15322 205
Corpus_Callosum_Forceps_Major 12 51.5018 2.60267 274

pre

Positive Corrs (FDR = 1.000000)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cingulum_Frontal_Parietal_L 13 52.9288 2.2742 215
Middle_Cerebellar_Peduncle 10 55.4085 2.20717 212

Neg Corrs (FDR = 0.033719)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1177 60.2053 10.319 5035
Fornix_R 455 57.4181 7.46495 2513
Corpus_Callosum_Forceps_Major 101 59.9111 6.57472 2034
Corpus_Callosum_Tapetum 87 60.103 6.74723 2149
Corpus_Callosum_Body 73 60.9683 6.62236 2100
Cerebellum_R 59 53.4923 4.9273 1020
Thalamic_Radiation_Superior_L 37 54.2194 4.37478 815
Cingulum_Frontal_Parietal_L 12 53.5183 1.41366 84

peri

Positive Corrs (FDR = 1.000000)

No significant results

Neg Corrs (FDR = 0.016568)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 118 59.7426 9.48688 4223
Corpus_Callosum_Forceps_Major 110 60.3932 9.31986 4120
Corpus_Callosum_Tapetum 93 60.8031 8.26103 3259
Cerebellum_R 80 53.9785 8.11526 2792
Fornix_L 70 62.0735 6.20158 1875
Corpus_Callosum_Forceps_Minor 63 57.4473 7.31003 2411
Cerebellum_L 54 53.4506 7.06095 2093
Inferior_Longitudinal_Fasciculus_R 23 60.1915 5.02983 1196
Corticostriatal_Tract_Posterior_R 22 53.2808 4.93707 1020
Thalamic_Radiation_Posterior_R 20 54.3022 4.69473 940
Arcuate_Fasciculus_R 19 55.0666 4.24676 780
Fornix_R 17 56.4813 3.0989 426
Cingulum_Frontal_Parietal_L 14 56.8687 3.53139 557
Middle_Cerebellar_Peduncle 14 59.8633 3.77214 669
Dentatorubrothalamic_Tract_L 13 57.3816 3.68205 611
Cingulum_Parolfactory_R 11 66.5657 2.11562 234
Dentatorubrothalamic_Tract_R 11 53.0841 3.89034 631
Reticular_Tract_R 11 56.5545 3.02704 407
Reticular_Tract_L 10 62.7878 3.05751 461

post

Positive Corrs (FDR = 1.000000)

No significant results

Neg Corrs (FDR = .065219))

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 429 55.5107 6.94688 2104
Fornix_L 293 55.8203 7.44036 2427

Peri + Post

Positive Corrs (FDR = 1.000000)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 149 56.2157 5.54391 1357
Cerebellum_R 84 52.6323 6.35795 1671
Fornix_R 19 56.2316 2.74179 332
Corpus_Callosum_Tapetum 16 52.8777 3.89174 629
Fornix_L 14 57.4393 2.97024 398
Arcuate_Fasciculus_L 11 63.4597 2.04776 209
Corpus_Callosum_Forceps_Major 10 57.6182 2.7731 348

Neg Corrs (FDR = 0.157199)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 379 57.8998 7.89017 2831
Corpus_Callosum_Tapetum 263 60.9206 8.76398 3675
Cingulum_Frontal_Parietal_R 69 57.5121 5.50927 1371
Cerebellum_R 69 53.4002 5.32892 1191
Thalamic_Radiation_Superior_L 50 56.4934 4.54116 915
Corpus_Callosum_Forceps_Major 48 60.0107 5.79171 1581
Corpus_Callosum_Forceps_Minor 47 54.8602 5.28396 1203
Fornix_R 37 52.9241 4.29562 767
Corpus_Callosum_Body 35 55.149 5.00266 1084
Corticospinal_Tract_L 31 53.2934 3.87962 630
Frontal_Aslant_Tract_L 28 56.2125 2.99493 396
Corticospinal_Tract_R 27 64.5277 3.77181 721
Inferior_Longitudinal_Fasciculus_L 24 52.254 3.83631 604
Cingulum_Frontal_Parietal_L 22 54.3651 4.02285 691
Cingulum_Parolfactory_R 20 57.3119 3.39887 520
Dentatorubrothalamic_Tract_R 19 60.5413 3.71717 657
Middle_Cerebellar_Peduncle 12 54.0049 2.13313 193

Loop Position Error Average

QA

All subjects

Men

Women

pre

peri

post

MD

All subjects

Men

Women

pre

peri

post

AD

All subjects

Men

Women

pre

peri

post

RD

All subjects

Men

Women

pre

peri

post

Loop Degree error Rad3

QA

Summary of Results

For all subjects, Degree error was correlated with QA values with age and sex marked as covariates. Tracts with QA values were both positively and negatively correlated with DE performance. When analyzed by sex, Men displayed tracts that were significantly negatively correlated with DE, DSI found no tracts positively correlated with DE (FDR=1.00). DSI studio found that tracts with QA in women displayed both positive and negative associations with DE performance. Women were further analyzed by menopause stage. Pre-menopause women displayed positive and negative relationships between tracts with QA and DE performance. DSI sutdio found that peri-menopause women displayed significant negative correlations between tracts with QA and DE and there were not significant positive correlations ( FDR= 0.7516098). Women in post menopause displayed no significant positive or negtive correlations (FDR= 1.000, 0.354664, respectively). When peri and post menopause women were grouped together, tracts with QA were positively and negatively correlated with DE performance

All subjects

Positive Corrs (FDR = 0.180868)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 349 55.4126 9.42135 3863
Uncinate_Fasciculus_R 184 58.7509 6.40167 1891
Superior_Longitudinal_Fasciculus2_R 119 55.8072 6.37801 1783
Inferior_Fronto_Occipital_Fasciculus_R 92 56.7042 5.57865 1386
Arcuate_Fasciculus_R 62 59.1987 5.14341 1230
Cingulum_Frontal_Parietal_R 53 54.9946 5.08536 1117
Inferior_Fronto_Occipital_Fasciculus_L 21 54.4779 3.14423 423
Uncinate_Fasciculus_L 19 55.2715 2.81094 343
Parietal_Aslant_Tract_R 10 52.3993 2.84455 333

Neg Corrs (FDR = 0.047850)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 283 57.4049 9.01854 3667
Corpus_Callosum_Tapetum 121 52.1369 8.19499 2750
Cerebellum_L 117 53.9887 5.7971 1425
Corpus_Callosum_Forceps_Major 78 54.8541 5.76128 1430
Optic_Radiation_L 46 53.2267 3.98842 665
Corticospinal_Tract_R 40 56.5032 4.67283 969
Inferior_Fronto_Occipital_Fasciculus_L 33 53.162 3.64915 556
Cingulum_Frontal_Parietal_R 29 54.1488 4.09454 713
Fornix_R 24 53.3508 3.44746 498
Fornix_L 22 53.2924 3.03286 385
Anterior_Commissure 13 52.7817 2.70355 303
Middle_Cerebellar_Peduncle 13 51.3942 3.22569 420
Inferior_Longitudinal_Fasciculus_L 10 50.9979 2.87904 332

Men

Positive Corrs (FDR = 1.000000)

Not significant

Neg Corrs (FDR = 0.212234)

Not significant

Women

Positive Corrs (FDR = 0.000325)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 1021 57.9318 12.7012 7340
Inferior_Fronto_Occipital_Fasciculus_R 429 61.3108 7.68513 2844
Uncinate_Fasciculus_R 318 59.9901 7.56301 2695
Superior_Longitudinal_Fasciculus2_R 129 56.4331 5.96302 1576
Arcuate_Fasciculus_R 95 61.5436 5.56326 1496
Cingulum_Frontal_Parietal_R 89 55.2862 5.40176 1267
Inferior_Fronto_Occipital_Fasciculus_L 45 54.7178 4.0903 719
Cingulum_Frontal_Parahippocampal_R 16 54.8773 3.48678 524

Neg Corrs (FDR = 0.002141)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 128 60.4652 5.94958 1681
Corpus_Callosum_Forceps_Major 67 58.4558 5.09541 1192
Corpus_Callosum_Tapetum 58 52.351 6.75475 1876
Cerebellum_L 55 53.1324 4.62077 891

pre

Positive Corrs (FDR = 0.020756)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 1071 59.5768 12.8688 7749
Inferior_Fronto_Occipital_Fasciculus_R 803 63.7896 9.82581 4837
Superior_Longitudinal_Fasciculus2_R 456 56.5196 9.74207 4213
Uncinate_Fasciculus_R 241 59.2559 6.83784 2176
Cingulum_Frontal_Parietal_R 176 59.6144 5.44274 1387
Middle_Cerebellar_Peduncle 172 56.3814 8.25146 3015
Arcuate_Fasciculus_R 125 58.7911 6.78069 2123
Corpus_Callosum_Forceps_Major 99 60.6149 6.59084 2068
Superior_Longitudinal_Fasciculus3_R 97 58.1526 6.27604 1799
Corticospinal_Tract_L 95 57.5871 6.95848 2190
Inferior_Fronto_Occipital_Fasciculus_L 93 55.3226 6.67853 1938
Corpus_Callosum_Body 83 55.3082 7.41598 2389
Arcuate_Fasciculus_L 77 57.8102 5.93626 1600
Corticospinal_Tract_R 74 58.9253 5.58196 1442
Cingulum_Parolfactory_R 72 65.1761 4.11311 866
Corpus_Callosum_Tapetum 53 53.2914 5.71911 1369
Reticular_Tract_R 28 59.0082 3.5891 597
Superior_Longitudinal_Fasciculus2_L 27 53.9315 4.0594 698
Thalamic_Radiation_Anterior_R 27 52.5299 4.02383 668
Medial_Lemniscus_L 21 56.2021 3.87557 663
Uncinate_Fasciculus_L 17 57.6619 2.94957 394
Anterior_Commissure 16 52.7544 3.17624 418
Cingulum_Frontal_Parietal_L 15 53.2061 2.25769 213
Frontal_Aslant_Tract_R 13 52.4662 3.40944 479
Inferior_Longitudinal_Fasciculus_R 12 53.5031 3.17275 423
Corticostriatal_Tract_Anterior_L 11 53.0968 2.85955 341

Neg Corrs (FDR = 0.067453)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 215 55.9956 9.05757 3608
Cerebellum_L 189 54.535 7.92195 2688
Corpus_Callosum_Forceps_Major 162 59.9477 6.22928 1827
Corpus_Callosum_Body 144 56.6362 7.15624 2278
Fornix_L 39 61.5921 4.44318 955
Vermis 16 51.6353 3.54623 510
Cingulum_Frontal_Parietal_L 11 54.5484 2.70725 314
Medial_Lemniscus_R 11 55.637 2.52229 278

peri

Positive Corrs (FDR = 0.751698)

No significant correlations

Neg Corrs (FDR = 0.067830)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 662 64.3498 18.7758 17817
Cerebellum_L 355 55.6881 15.2368 10154
Cerebellum_R 289 54.4109 14.4872 8969
Middle_Cerebellar_Peduncle 213 61.1463 12.1779 7122
Inferior_Fronto_Occipital_Fasciculus_R 209 61.6887 11.3058 6193
Corpus_Callosum_Forceps_Major 179 60.8784 12.0207 6909
Corpus_Callosum_Tapetum 170 61.5825 11.6983 6619
Corpus_Callosum_Forceps_Minor 143 59.9763 10.8438 5539
Arcuate_Fasciculus_L 140 58.5826 10.522 5094
Arcuate_Fasciculus_R 118 67.0445 8.90221 4173
Corticospinal_Tract_L 108 60.5047 9.44033 4235
Superior_Longitudinal_Fasciculus2_R 107 62.5326 8.67849 3699
Inferior_Longitudinal_Fasciculus_R 105 60.2169 9.75552 4501
Inferior_Longitudinal_Fasciculus_L 99 61.7253 8.55852 3551
Inferior_Fronto_Occipital_Fasciculus_L 98 62.4148 8.60408 3629
Cingulum_Frontal_Parietal_R 87 64.3309 7.09724 2545
Dentatorubrothalamic_Tract_L 83 57.2363 9.27004 3863
Cingulum_Frontal_Parietal_L 76 59.6695 6.80313 2169
Frontal_Aslant_Tract_L 74 61.6571 8.36071 3385
Superior_Longitudinal_Fasciculus2_L 71 60.1783 8.42523 3355
Corticostriatal_Tract_Posterior_L 69 62.5321 8.44667 3504
Corticospinal_Tract_R 68 64.367 7.9908 3228
Corticostriatal_Tract_Superior_L 61 55.9756 7.96204 2787
Medial_Lemniscus_L 57 58.2948 6.64226 2020
Corticostriatal_Tract_Posterior_R 48 60.4274 7.57603 2724
Optic_Radiation_L 41 56.2988 5.34238 1262
Dentatorubrothalamic_Tract_R 40 57.6617 6.77383 2078
Cingulum_Parahippocampal_Parietal_R 37 56.8785 5.38414 1295
Cingulum_Parolfactory_R 34 63.5997 4.4855 1005
Medial_Lemniscus_R 31 62.6518 5.5725 1528
Corticostriatal_Tract_Superior_R 28 57.8696 5.78868 1523
Thalamic_Radiation_Posterior_R 28 59.2231 5.56598 1441
Cingulum_Parolfactory_L 27 56.1484 2.85718 360
Corticopontine_Tract_Parietal_L 26 66.5467 5.2087 1418
Extreme_Capsule_L 25 58.6456 4.73573 1033
Thalamic_Radiation_Posterior_L 23 56.0896 5.42396 1296
Fornix_L 23 55.6651 4.04688 716
Superior_Longitudinal_Fasciculus3_R 20 61.1053 4.43038 942
Vermis 20 56.207 4.6706 963
Anterior_Commissure 18 66.8917 4.34754 993
Uncinate_Fasciculus_L 17 58.8176 3.52805 575
Extreme_Capsule_R 16 55.2609 4.11799 736
Corticopontine_Tract_Parietal_R 15 66.4311 4.47964 1047
Thalamic_Radiation_Superior_L 15 53.2275 3.85108 620
Parietal_Aslant_Tract_L 13 55.253 3.93808 673
Fornix_R 13 70.47 2.96022 485
Superior_Longitudinal_Fasciculus3_L 12 58.1728 3.87487 686
Superior_Longitudinal_Fasciculus1_R 11 65.2688 3.87064 768
Uncinate_Fasciculus_R 11 62.9109 3.18745 502
Thalamic_Radiation_Anterior_R 11 59.6429 3.7365 654
Middle_Longitudinal_Fasciculus_L 10 55.8239 3.57068 559
Middle_Longitudinal_Fasciculus_R 10 56.4026 3.77715 632
Reticular_Tract_L 10 61.8136 3.59947 629

post

Positive Corrs(FDR = 1.000000)

No significant correlations

Neg Corrs (FDR = 0.354664)

No significant correlations

Peri + Post

Positive Corrs(FDR = 0.009696)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 1622 63.902 18.3067 16820
Corpus_Callosum_Forceps_Minor 1404 59.763 15.887 11847
Corpus_Callosum_Forceps_Major 806 66.387 12.7898 8529
Corpus_Callosum_Tapetum 560 61.5853 13.2782 8528
Corticospinal_Tract_R 509 60.9721 9.7636 4565
Cingulum_Frontal_Parietal_R 415 60.5383 8.49103 3428
Medial_Lemniscus_R 306 58.1572 9.80472 4391
Inferior_Fronto_Occipital_Fasciculus_R 198 57.7676 7.69138 2684
Arcuate_Fasciculus_R 155 59.5448 8.13774 3097
Middle_Cerebellar_Peduncle 142 54.264 7.42721 2351
Uncinate_Fasciculus_R 131 61.076 6.272 1887
Dentatorubrothalamic_Tract_R 107 57.6358 8.41308 3204
Thalamic_Radiation_Anterior_R 98 58.79 6.01037 1668
Superior_Longitudinal_Fasciculus1_R 97 57.6798 6.10963 1691
Corticostriatal_Tract_Posterior_R 83 55.5504 7.81849 2667
Cingulum_Parolfactory_R 77 60.4195 5.14267 1255
Corticopontine_Tract_Parietal_R 75 60.7556 7.30308 2545
Parietal_Aslant_Tract_R 62 56.5647 4.92369 1077
Cingulum_Frontal_Parahippocampal_R 56 57.0471 4.63608 963
Cingulum_Frontal_Parietal_L 56 56.0541 5.23606 1207
Superior_Longitudinal_Fasciculus2_L 54 59.3435 5.03377 1181
Thalamic_Radiation_Posterior_R 44 60.4682 4.86923 1126
Corticostriatal_Tract_Anterior_R 42 53.5792 5.6703 1353
Superior_Longitudinal_Fasciculus2_R 35 53.4432 5.1494 1113
Corticostriatal_Tract_Superior_R 35 57.2057 5.20238 1216
Arcuate_Fasciculus_L 32 59.2593 5.1969 1257
Frontal_Aslant_Tract_L 30 56.5996 3.58085 570
Reticular_Tract_R 29 58.6385 4.82235 1071
Inferior_Fronto_Occipital_Fasciculus_L 28 66.5794 4.13017 892
Cingulum_Parahippocampal_Parietal_R 23 56.5219 3.65489 593
Middle_Longitudinal_Fasciculus_L 23 55.1418 3.53111 540
Extreme_Capsule_L 18 60.5783 4.04637 779
Corticostriatal_Tract_Anterior_L 18 53.4413 3.26705 448
Extreme_Capsule_R 16 59.888 4.15493 812
Inferior_Longitudinal_Fasciculus_R 15 53.6198 3.59742 545
Superior_Longitudinal_Fasciculus1_L 15 59.7427 3.12425 458
Corticostriatal_Tract_Posterior_L 15 57.2292 3.8028 650
Corticopontine_Tract_Frontal_R 13 54.4597 3.28654 462
Corticostriatal_Tract_Superior_L 13 52.6233 3.82282 604
Cingulum_Parolfactory_L 12 51.6763 2.82105 323
Inferior_Longitudinal_Fasciculus_L 12 57.345 3.68624 612
Corticospinal_Tract_L 12 53.8482 3.34426 473
Anterior_Commissure 12 55.8474 2.39216 251
Fornix_R 11 53.4689 3.02392 384
Corticopontine_Tract_Occipital_R 10 53.2044 2.54193 270

Neg Corrs (FDR = 0.099355)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 135 54.3717 7.15637 2187
Cerebellum_R 100 53.7922 8.01642 2715
Middle_Cerebellar_Peduncle 30 53.9386 3.95605 663
Cingulum_Parolfactory_L 25 57.371 2.46144 273
Arcuate_Fasciculus_L 18 53.9059 3.54814 533
Corpus_Callosum_Body 13 53.546 3.70407 577
Cingulum_Frontal_Parietal_L 10 54.2132 2.18349 203

MD

Summary of Results

Tracts with MD were positively correlated with DE performance when all subjects were analyzed. In men, there were no significantly correlated tracts associated with DE performance. In women, tracts with MD were positively associated with DE performance. Pre-menopause women displayed MD tracts with significantly positively correlations to DE. Peri and Post -menopause women displayed significantly negative relationships between MD and DE performance when analyzed seperately. When analyzed together, tracts were positively correlated with DE.

All Subjects

Positive Corrs (FDR = 0.029053)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1102 58.9383 9.09611 3830
Fornix_R 567 56.1865 7.41913 2429
Thalamic_Radiation_Superior_L 46 54.7424 4.20159 759
Corpus_Callosum_Tapetum 15 53.8882 2.81759 336
Cingulum_Frontal_Parietal_L 14 56.0045 2.65475 310
Corpus_Callosum_Forceps_Major 10 52.4029 2.5802 274

Neg Corrs (FDR = 1.0000)

Not significant

Men

Positive Corrs Not significant (FDR = 0.667369)

Not significant

Neg Corrs (FDR = 1.0000)

Not significant

Women

Positive Corrs (FDR = 0.065079)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 782 57.1293 9.88915 4388
Fornix_R 377 54.5825 7.47449 2395
Corpus_Callosum_Tapetum 97 53.9487 6.17569 1616
Corpus_Callosum_Forceps_Major 74 55.1716 5.46678 1295
Thalamic_Radiation_Superior_L 33 54.9695 4.13169 737
Cerebellum_R 10 52.5984 2.47474 253

Neg Corrs (FDR = 0.004739)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 90 53.6326 5.23412 1154

pre

Positive Corrs (FDR = 0.146316)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 505 60.2471 8.31941 3275
Fornix_R 166 56.7425 6.62161 1954
Corpus_Callosum_Forceps_Major 145 58.0109 6.7404 2070
Cerebellum_R 82 53.2532 6.52184 1779
Corpus_Callosum_Tapetum 22 53.2703 3.84954 620
Thalamic_Radiation_Superior_R 19 57.4829 2.87435 373
Thalamic_Radiation_Superior_L 18 55.0084 2.96573 380
Optic_Radiation_L 16 53.2582 3.23962 439

Neg Corrs (FDR = 1.000000)

Not significant

peri

Positive Corrs (FDR = 1.000000)

Not significant

Neg Corrs (FDR = 0.022007)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 194 61.4 11.9713 6911
Cerebellum_R 166 55.5612 11.441 5712
Corpus_Callosum_Tapetum 158 61.2292 11.7753 6668
Corpus_Callosum_Body 148 60.4303 11.4441 6216
Cerebellum_L 96 54.0528 8.28781 2916
Inferior_Longitudinal_Fasciculus_R 79 61.2021 8.94492 3846
Corticostriatal_Tract_Posterior_R 64 57.8857 7.99773 2908
Corpus_Callosum_Forceps_Minor 52 56.631 7.77975 2692
Arcuate_Fasciculus_R 50 60.8534 6.40874 1963
Arcuate_Fasciculus_L 48 55.8042 6.05898 1609
Fornix_L 43 61.1201 6.61413 2100
Inferior_Longitudinal_Fasciculus_L 33 63.2857 5.84826 1700
Inferior_Fronto_Occipital_Fasciculus_R 28 58.7835 5.69808 1499
Superior_Longitudinal_Fasciculus2_R 23 55.6632 5.31501 1235
Inferior_Fronto_Occipital_Fasciculus_L 22 63.9277 5.17381 1344
Middle_Cerebellar_Peduncle 20 58.6076 4.07403 764
Superior_Longitudinal_Fasciculus2_L 16 59.0182 4.25952 841
Uncinate_Fasciculus_R 15 54.5316 3.91366 656
Thalamic_Radiation_Posterior_L 15 54.1366 4.57 888
Dentatorubrothalamic_Tract_R 15 60.5337 3.83712 700
Dentatorubrothalamic_Tract_L 14 55.0038 4.26007 784
Parietal_Aslant_Tract_R 13 54.7754 3.69072 586
Superior_Longitudinal_Fasciculus1_R 13 55.5367 3.46602 524
Anterior_Commissure 13 62.9288 3.5016 606
Cingulum_Parahippocampal_Parietal_R 12 56.8391 3.73273 622
Corticostriatal_Tract_Posterior_L 12 59.1718 4.136 795
Thalamic_Radiation_Posterior_R 12 55.3345 4.13199 742
Medial_Lemniscus_R 12 57.169 3.92012 690
Optic_Radiation_L 12 54.0063 4.10569 715
Cingulum_Frontal_Parietal_L 11 61.0874 3.11319 465
Thalamic_Radiation_Superior_L 10 58.0198 3.52432 566
Medial_Lemniscus_L 10 53.2275 2.90586 353

post

Positive Corrs (FDR = 1.000000)

Not significant

Neg Corrs (FDR = 0.028408)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 271 63.5699 12.1455 7365
Cerebellum_R 239 55.9171 13.8456 8419
Corpus_Callosum_Tapetum 178 68.0098 10.8689 6310
Inferior_Longitudinal_Fasciculus_R 162 60.0737 10.9343 5641
Cerebellum_L 130 54.5338 10.3442 4583
Arcuate_Fasciculus_L 128 61.9484 8.91627 3868
Inferior_Longitudinal_Fasciculus_L 118 64.3014 9.33195 4398
Corpus_Callosum_Body 78 59.3181 9.07404 3836
Middle_Cerebellar_Peduncle 76 59.1945 7.22519 2427
Inferior_Fronto_Occipital_Fasciculus_R 64 57.2883 8.00052 2880
Corticostriatal_Tract_Posterior_R 61 58.0751 7.12573 2316
Fornix_L 59 56.6878 5.95527 1579
Superior_Longitudinal_Fasciculus2_L 50 57.37 6.91891 2157
Corpus_Callosum_Forceps_Minor 47 59.7577 7.00039 2300
Corticostriatal_Tract_Posterior_L 43 63.1306 6.58191 2148
Arcuate_Fasciculus_R 40 65.0155 5.58891 1595
Fornix_R 26 60.9299 3.0869 456
Thalamic_Radiation_Posterior_L 25 56.0088 5.56845 1364
Inferior_Fronto_Occipital_Fasciculus_L 24 57.7535 5.11123 1185
Thalamic_Radiation_Posterior_R 20 58.1078 4.73683 1024
Medial_Lemniscus_R 19 63.3737 4.77738 1136
Cingulum_Parahippocampal_Parietal_R 18 53.5647 3.94581 655
Frontal_Aslant_Tract_L 18 66.0046 4.29659 957
Dentatorubrothalamic_Tract_L 18 62.8991 4.39217 953
Superior_Longitudinal_Fasciculus2_R 17 58.352 4.61715 977
Corticostriatal_Tract_Anterior_L 17 55.0693 4.52603 886
Thalamic_Radiation_Superior_L 17 58.6989 3.49147 562
Dentatorubrothalamic_Tract_R 15 55.4647 3.62364 572
Optic_Radiation_L 14 54.8497 3.94371 670
Corticopontine_Tract_Parietal_L 13 56.6231 3.80836 645
Middle_Longitudinal_Fasciculus_R 12 70.0286 3.65064 733
Parietal_Aslant_Tract_L 12 58.5243 3.10798 444
Corticopontine_Tract_Parietal_R 11 59.6601 3.82348 685
Corticospinal_Tract_R 11 59.2704 3.39327 536
Thalamic_Radiation_Anterior_R 11 60.724 3.59681 617
Reticular_Tract_L 11 59.0983 3.5166 574

Peri + Post

Positive Corrs (FDR = 0.150602)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 427 57.6254 7.42329 2494
Corpus_Callosum_Tapetum 215 58.5033 6.48606 1933
Fornix_R 137 54.1106 4.96349 1047
Cerebellum_R 105 52.9458 6.3201 1661
Thalamic_Radiation_Superior_L 38 57.1603 3.75796 634
Cerebellum_L 18 53.1184 3.08092 396
Cingulum_Frontal_Parietal_L 10 55.4036 2.20205 211

Neg Corrs (FDR = 0.219578)

Not significant

AD

Summary of Results

All subjects

Positive Corrs (FDR = 0.019142)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 714 56.0556 8.97333 3545
Fornix_R 701 55.306 8.26471 2967
Thalamic_Radiation_Superior_L 54 56.407 4.02017 716

Neg Corrs (FDR = 1.000000)

No Significant Findings

Men

Positive Corrs (FDR = 0.663721)

No Significant Findings

Neg Corrs (FDR = 1.000000)

No Significant Findings

Women

Positive Corrs (FDR = 0.056502)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 677 55.9265 9.80405 4222
Fornix_R 335 53.9199 7.46354 2359
Thalamic_Radiation_Superior_L 75 57.6603 5.37839 1310
Corpus_Callosum_Forceps_Major 72 55.2321 5.17785 1163
Cingulum_Frontal_Parietal_L 53 58.2366 3.56406 581
Corpus_Callosum_Tapetum 49 55.072 4.84898 1017
Thalamic_Radiation_Anterior_L 23 57.0711 2.10174 198
Cingulum_Frontal_Parahippocampal_L 14 61.883 2.68351 350

Neg Corrs (FDR = 0.002967)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 106 54.7043 5.18932 1157
Inferior_Longitudinal_Fasciculus_L 17 54.4825 3.27873 460
Fornix_R 16 56.1323 3.01216 400
Cerebellum_L 13 52.4591 2.39332 236
Optic_Radiation_L 12 52.996 2.84543 337

pre

Positive Corrs (FDR = 0.158581))

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 520 57.6047 8.47555 3250
Corpus_Callosum_Forceps_Major 288 57.1979 8.64838 3360
Fornix_R 232 55.9383 7.41871 2418
Cerebellum_R 144 53.3705 8.20653 2823
Corpus_Callosum_Forceps_Minor 74 55.3301 4.8162 1008
Thalamic_Radiation_Superior_L 44 53.6068 4.99865 1052
Corpus_Callosum_Tapetum 38 53.644 5.03006 1066
Optic_Radiation_L 33 53.2199 4.6915 920
Thalamic_Radiation_Superior_R 28 53.2932 3.75762 591
Cerebellum_L 21 52.8831 3.62239 545
Anterior_Commissure 13 55.8681 3.18816 446

Neg Corrs (FDR = 1.000000)

No Significant Findings

peri

Positive Corrs (FDR = 1.000000)

No Significant Findings

Neg Corrs (FDR = 0.011568)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 169 68.1529 11.8882 7565
Cerebellum_R 165 54.6619 11.372 5552
Corpus_Callosum_Forceps_Major 108 63.6231 9.39329 4409
Cerebellum_L 108 54.5789 8.63737 3198
Corpus_Callosum_Body 90 59.914 8.99697 3809
Inferior_Longitudinal_Fasciculus_L 67 56.816 7.23994 2339
Middle_Cerebellar_Peduncle 39 55.7965 5.86419 1507
Inferior_Fronto_Occipital_Fasciculus_R 37 55.0781 6.7535 1973
Corticostriatal_Tract_Posterior_R 37 57.4177 6.89355 2143
Arcuate_Fasciculus_L 34 59.546 5.92176 1640
Fornix_L 34 60.8892 6.07515 1765
Inferior_Longitudinal_Fasciculus_R 29 58.4916 6.28733 1816
Inferior_Fronto_Occipital_Fasciculus_L 25 58.5688 5.55996 1422
Arcuate_Fasciculus_R 24 61.7605 5.14296 1283
Corticostriatal_Tract_Posterior_L 24 57.5034 4.93968 1102
Cingulum_Parolfactory_R 20 61.9114 4.30221 900
Optic_Radiation_L 20 58.9132 4.59981 979
Cingulum_Frontal_Parietal_R 19 59.2764 4.65543 1009
Superior_Longitudinal_Fasciculus2_L 19 56.8535 4.0211 722
Corticospinal_Tract_R 19 61.9096 4.47565 974
Corticospinal_Tract_L 18 63.2341 4.50516 1008
Thalamic_Radiation_Posterior_L 17 58.9506 4.6007 980
Dentatorubrothalamic_Tract_R 17 58.7184 4.43477 907
Corpus_Callosum_Forceps_Minor 16 57.3883 4.72435 1006
Anterior_Commissure 14 59.1598 3.72004 643
Middle_Longitudinal_Fasciculus_R 13 55.085 4.07948 720
Cingulum_Parahippocampal_Parietal_R 12 54.5133 3.44796 509
Superior_Longitudinal_Fasciculus2_R 12 53.5178 3.99546 671
Corticopontine_Tract_Parietal_L 12 64.6643 3.71519 701
Medial_Lemniscus_R 12 60.3441 3.6546 633
Thalamic_Radiation_Posterior_R 11 59.8274 3.89538 713
Dentatorubrothalamic_Tract_L 11 55.8278 3.60551 570
Thalamic_Radiation_Superior_L 10 55.4127 3.66317 584

post

Positive Corrs (FDR = 1.000000)

No Significant Findings

Neg Corrs (FDR = 0.036173)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 163 55.2628 11.3993 5640
Cerebellum_L 104 54.0143 9.13229 3538
Corpus_Callosum_Tapetum 63 60.2589 7.23886 2480
Inferior_Longitudinal_Fasciculus_R 56 55.4422 6.72788 1971
Corpus_Callosum_Forceps_Major 53 59.7037 6.67777 2091
Inferior_Fronto_Occipital_Fasciculus_R 34 53.4819 5.76494 1396
Fornix_L 30 59.8712 4.64371 1014
Middle_Cerebellar_Peduncle 28 54.2892 5.36221 1226
Arcuate_Fasciculus_L 20 54.3013 4.87365 1013
Inferior_Longitudinal_Fasciculus_L 19 56.6479 4.42204 870
Fornix_R 19 60.6331 3.12819 466
Corticostriatal_Tract_Posterior_R 17 53.1937 4.41405 814
Thalamic_Radiation_Superior_L 15 58.0113 3.25928 484
Arcuate_Fasciculus_R 13 57.8492 3.66413 610
Corticostriatal_Tract_Superior_R 10 53.411 2.56504 276
Corpus_Callosum_Body 10 57.5923 3.59011 583

Peri + Post

Positive Corrs (FDR = 0.109957)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 482 54.6979 8.14359 2849
Fornix_R 223 53.6774 6.73975 1915
Corpus_Callosum_Tapetum 182 58.9873 5.82878 1574
Cerebellum_R 131 54.0877 6.38343 1731
Thalamic_Radiation_Superior_L 71 56.2298 5.12508 1160
Cerebellum_L 33 54.3178 3.95113 666

Neg Corrs (FDR = 0.602679)

No Significant Findings

RD

Summary

All subjects

Positive Corrs (FDR = 0.027027)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1110 58.9889 8.94864 3710
Fornix_R 617 56.7757 7.61385 2585
Thalamic_Radiation_Superior_L 45 54.9321 4.31151 802
Corpus_Callosum_Tapetum 15 53.8925 2.05069 178

Neg Corrs (FDR = 1.000000)

No Significant Findings

Men

Positive Corrs (Not Significant?) (FDR = 0.553308) No Significant Findings

Neg Corrs (FDR = 1.000000)

No Significant Findings

Women

Positive Corrs (FDR = 0.105231)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1372 57.8165 11.0265 5521
Fornix_R 540 55.0571 7.97616 2751
Corpus_Callosum_Tapetum 211 54.3779 8.80488 3311
Corpus_Callosum_Forceps_Major 150 55.5525 6.92112 2090
Thalamic_Radiation_Superior_L 77 57.1464 6.0171 1625
Cingulum_Frontal_Parietal_L 72 59.101 4.15148 800
Cingulum_Frontal_Parahippocampal_L 32 64.3257 4.19954 891
Thalamic_Radiation_Anterior_L 29 54.632 2.81081 339
Cerebellum_R 12 52.0263 3.03748 377
Optic_Radiation_L 11 52.0002 2.79478 319

Neg Corrs (FDR = 0.063559)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 122 53.923 5.61026 1333
Corpus_Callosum_Forceps_Minor 74 53.0905 4.93378 1015
Fornix_R 20 52.7018 3.25668 439
Middle_Longitudinal_Fasciculus_R 16 53.6393 2.97555 373
Cerebellum_L 10 52.4046 2.91611 350

pre

Positive Corrs (FDR = 0.181320))

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 989 61.09 9.76805 4578
Fornix_R 571 57.3213 8.97575 3627
Corpus_Callosum_Forceps_Major 235 58.5446 7.50519 2590
Cerebellum_R 93 53.3626 7.02275 2067
Corpus_Callosum_Tapetum 87 56.3269 7.01175 2175
Thalamic_Radiation_Superior_L 35 54.9227 4.50127 874
Corpus_Callosum_Body 24 55.5858 4.50749 887
Cerebellum_L 18 52.575 3.40946 480
Thalamic_Radiation_Superior_R 12 52.4981 3.51352 509
Optic_Radiation_L 10 53.0064 2.64839 292

Neg Corrs (FDR = 1.000000)

No Significant Findings

peri

Positive Corrs (FDR = 1.000000)

No Significant Findings

Neg Corrs (FDR = 0.020058)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 127 59.3316 9.53208 4234
Corpus_Callosum_Body 82 58.9622 9.06215 3803
Cerebellum_R 73 54.7961 8.60945 3190
Corpus_Callosum_Tapetum 67 58.7512 8.14476 3061
Cerebellum_L 52 53.3141 6.92838 2010
Corpus_Callosum_Forceps_Minor 43 57.3209 6.63849 1984
Inferior_Longitudinal_Fasciculus_R 19 61.0702 4.62051 1024
Fornix_L 18 62.2422 4.79508 1124
Corticostriatal_Tract_Posterior_R 17 53.4248 4.72556 937
Arcuate_Fasciculus_R 15 56.2796 4.06666 731
Thalamic_Radiation_Posterior_R 15 55.2023 4.38591 834
Middle_Cerebellar_Peduncle 15 58.9334 3.8103 672
Cingulum_Frontal_Parietal_L 14 58.3098 3.96507 720
Cingulum_Parolfactory_R 14 61.7313 2.47503 297
Superior_Longitudinal_Fasciculus2_R 13 62.4769 3.6647 659
Superior_Longitudinal_Fasciculus1_R 11 56.3646 3.22702 461

post

Positive Corrs (FDR = 1.000000)

No Significant Findings

Neg Corrs (FDR = 0.035618)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 230 64.1165 11.9657 7210
Cerebellum_R 225 55.4225 13.7812 8267
Corpus_Callosum_Body 183 61.5238 12.5668 7631
Corpus_Callosum_Tapetum 177 64.4304 11.564 6767
Inferior_Longitudinal_Fasciculus_L 114 66.4855 8.63665 3895
Arcuate_Fasciculus_L 112 62.3151 8.82772 3814
Cerebellum_L 110 55.3264 9.84773 4214
Corpus_Callosum_Forceps_Minor 96 57.4237 9.52411 4091
Inferior_Longitudinal_Fasciculus_R 88 59.9403 9.39353 4154
Fornix_L 86 58.1021 6.69104 2043
Middle_Cerebellar_Peduncle 84 59.0963 8.0637 3018
Inferior_Fronto_Occipital_Fasciculus_R 49 56.5742 7.2352 2326
Dentatorubrothalamic_Tract_R 48 62.4294 6.40263 2010
Corticostriatal_Tract_Posterior_L 46 64.4861 6.68295 2262
Corticostriatal_Tract_Posterior_R 45 57.4733 6.5473 1935
Cingulum_Frontal_Parietal_R 38 62.6973 5.57048 1528
Superior_Longitudinal_Fasciculus2_L 38 57.009 6.09255 1662
Dentatorubrothalamic_Tract_L 32 59.3868 6.27232 1835
Arcuate_Fasciculus_R 30 59.2057 5.85854 1596
Corticopontine_Tract_Parietal_L 29 65.2493 5.13636 1352
Thalamic_Radiation_Posterior_R 28 57.9266 5.26052 1259
Thalamic_Radiation_Posterior_L 27 58.3791 5.1456 1214
Medial_Lemniscus_L 26 57.4663 4.75621 1021
Medial_Lemniscus_R 26 62.2409 4.76303 1109
Inferior_Fronto_Occipital_Fasciculus_L 25 61.8548 5.38738 1410
Fornix_R 24 57.8261 3.16518 455
Frontal_Aslant_Tract_L 22 63.0986 4.78568 1135
Corticospinal_Tract_R 20 61.2025 4.17534 838
Superior_Longitudinal_Fasciculus2_R 19 58.7469 4.38455 887
Cingulum_Parolfactory_R 14 70.862 3.07719 527
Parietal_Aslant_Tract_L 14 61.7206 3.68708 659
Corticostriatal_Tract_Superior_R 14 51.5776 4.43561 797
Cingulum_Parahippocampal_Parietal_R 13 57.8576 3.72049 629
Corticostriatal_Tract_Anterior_R 13 52.7697 4.21979 738
Cingulum_Frontal_Parietal_L 12 56.1824 3.60042 572
Parietal_Aslant_Tract_R 12 55.5208 3.71248 601
Thalamic_Radiation_Superior_L 12 66.1783 3.39194 598
Extreme_Capsule_L 11 62.5425 3.59546 635
Extreme_Capsule_R 11 57.0932 3.76313 635
Middle_Longitudinal_Fasciculus_L 11 65.6455 3.85197 765
Middle_Longitudinal_Fasciculus_R 11 61.4663 3.55177 609
Corticopontine_Tract_Parietal_R 11 58.5549 3.40437 533
Thalamic_Radiation_Anterior_R 11 57.6448 3.79197 651
Reticular_Tract_L 11 54.5581 3.58267 550
Superior_Longitudinal_Fasciculus1_R 10 59.8195 3.4923 573
Corticospinal_Tract_L 10 56.1934 3.15747 440
Thalamic_Radiation_Anterior_L 10 53.8025 3.73029 588

Peri + Post

Positive Corrs (FDR = 0.141074)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 347 58.0147 7.10013 2297
Corpus_Callosum_Tapetum 200 57.9615 6.34724 1834
Cerebellum_R 86 52.5709 5.98706 1480
Fornix_R 77 54.5797 4.64526 925
Cerebellum_L 29 54.0811 4.28254 779
Thalamic_Radiation_Superior_L 24 55.8395 3.42013 513
Cingulum_Frontal_Parietal_L 13 59.8421 2.77528 362
Cingulum_Frontal_Parahippocampal_L 12 64.8506 3.05704 476
Inferior_Fronto_Occipital_Fasciculus_L 12 52.5052 2.7285 307

Neg Corrs (FDR = 0.240841)

No Significant Findings

Loop Degree error average

QA

All subjects

Men

Women

pre

peri

post

MD

All subjects

Men

Women

pre

peri

post

AD

All subjects

Men

Women

pre

peri

post

RD

All subjects

Men

Women

pre

peri

post

Loop angular error Rad3

QA

Summary

All subjects

Positive Corrs (FDR = 0.000675)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 877 55.9796 12.0679 6403
Cerebellum_L 64 53.1643 4.58556 878
Fornix_R 12 52.1689 2.5954 276
Cingulum_Frontal_Parietal_L 10 52.4089 1.953 157

Neg Corrs (FDR = 0.004296)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corticospinal_Tract_R 304 55.1267 8.55124 3166
Arcuate_Fasciculus_R 182 52.5773 5.35013 1182
Medial_Lemniscus_R 52 56.3921 4.97225 1095
Corpus_Callosum_Tapetum 23 52.788 3.23916 435

Men

Positive Corrs (FDR = 0.012481)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 994 58.7371 13.4206 8309
Cerebellum_L 631 56.935 10.6459 5068
Cerebellum_R 249 53.6912 9.48158 3791
Corticospinal_Tract_R 238 59.1276 7.75247 2791
Corpus_Callosum_Tapetum 170 59.6702 9.6741 4386
Arcuate_Fasciculus_L 159 55.8202 7.70542 2603
Inferior_Fronto_Occipital_Fasciculus_R 156 57.063 6.75498 2045
Corpus_Callosum_Body 154 59.7992 9.43738 4183
Superior_Longitudinal_Fasciculus2_R 129 56.3811 7.73299 2648
Arcuate_Fasciculus_R 116 57.8156 7.73957 2720
Superior_Longitudinal_Fasciculus3_R 96 60.4046 6.44723 1972
Medial_Lemniscus_R 90 56.6319 6.76737 2037
Corticostriatal_Tract_Superior_R 69 55.5161 5.76474 1449
Vermis 63 53.215 5.77937 1396
Corpus_Callosum_Forceps_Major 59 62.0339 6.02566 1769
Cingulum_Frontal_Parietal_L 53 61.7079 3.18616 492
Inferior_Longitudinal_Fasciculus_R 51 54.9511 5.04392 1098
Corticopontine_Tract_Parietal_R 50 60.2026 5.63052 1499
Thalamic_Radiation_Posterior_L 47 54.3075 5.31519 1205
Middle_Cerebellar_Peduncle 47 67.1561 4.36728 1006
Corticopontine_Tract_Parietal_L 39 57.7474 5.65617 1451
Corticostriatal_Tract_Posterior_L 38 65.009 5.66576 1639
Thalamic_Radiation_Anterior_R 34 57.6071 3.81935 660
Corticostriatal_Tract_Posterior_R 33 55.2883 5.01246 1091
Inferior_Fronto_Occipital_Fasciculus_L 18 55.2274 3.66302 582
Parietal_Aslant_Tract_L 18 61.678 2.37395 273
Cingulum_Frontal_Parahippocampal_L 15 57.4842 2.63722 314
Cingulum_Parolfactory_L 13 65.2353 2.72336 380
Extreme_Capsule_R 13 53.9993 3.22829 442
Frontal_Aslant_Tract_R 13 54.6191 3.28883 464
Dentatorubrothalamic_Tract_R 13 52.9296 2.95094 362

Neg Corrs (FDR = 0.024096)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 116 55.5436 7.63954 2546

Women

Positive Corrs (FDR = 0.015385)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_L 35 54.407 3.71266 589

Neg Corrs (FDR = 0.001027)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corticospinal_Tract_R 239 55.4744 7.1526 2229
Arcuate_Fasciculus_R 114 54.341 4.77717 974
Medial_Lemniscus_R 95 57.0645 4.7495 1011
Corpus_Callosum_Tapetum 60 54.4736 4.43891 843
Inferior_Longitudinal_Fasciculus_R 25 57.4453 3.14057 445
Corticostriatal_Tract_Superior_R 20 53.9077 3.42961 498
Cingulum_Frontal_Parietal_L 16 53.6303 2.50826 265
Dentatorubrothalamic_Tract_R 15 51.746 3.22617 423

pre

Positive Corrs (FDR = 0.036981)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Major 532 62.1823 10.7882 5684
Corpus_Callosum_Tapetum 438 55.1425 11.7919 6022
Corpus_Callosum_Body 346 59.1443 9.77555 4439
Cerebellum_L 155 55.1539 7.57713 2487
Corpus_Callosum_Forceps_Minor 134 57.2479 7.07245 2249
Fornix_L 60 61.0718 4.38192 921
Fornix_R 57 56.4362 3.77901 633
Arcuate_Fasciculus_L 50 54.402 3.53524 534
Inferior_Longitudinal_Fasciculus_L 27 56.5924 5.23694 1219
Thalamic_Radiation_Posterior_L 24 53.8504 4.31094 786
Corticostriatal_Tract_Posterior_L 20 54.8058 3.57456 550
Cingulum_Frontal_Parietal_R 14 62.1548 2.87679 404

Neg Corrs (FDR = 0.009185)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Inferior_Fronto_Occipital_Fasciculus_R 510 63.0641 9.04814 4055
Corticospinal_Tract_L 271 57.1097 11.0875 5514
Inferior_Fronto_Occipital_Fasciculus_L 262 56.5833 7.10437 2243
Corticospinal_Tract_R 251 58.6942 8.60702 3415
Cerebellum_L 222 56.1792 7.86447 2729
Cingulum_Frontal_Parietal_L 204 55.5582 6.13807 1644
Middle_Cerebellar_Peduncle 174 55.7707 8.49636 3162
Corpus_Callosum_Tapetum 162 60.7 7.25022 2506
Inferior_Longitudinal_Fasciculus_R 148 58.2545 5.78277 1530
Arcuate_Fasciculus_L 117 58.4216 7.03056 2268
Medial_Lemniscus_L 114 57.2181 7.15872 2303
Corticostriatal_Tract_Superior_L 107 56.5335 8.3584 3102
Medial_Lemniscus_R 80 55.1851 6.23326 1684
Dentatorubrothalamic_Tract_L 70 55.1835 7.00213 2125
Cingulum_Parolfactory_R 69 59.4306 3.99242 744
Arcuate_Fasciculus_R 64 60.978 6.21183 1848
Superior_Longitudinal_Fasciculus2_R 64 56.7607 5.33534 1269
Cingulum_Frontal_Parietal_R 62 55.4943 5.40012 1271
Corpus_Callosum_Body 53 54.5364 5.5849 1336
Uncinate_Fasciculus_R 51 56.2061 4.06932 731
Vermis 50 53.4535 4.85852 991
Corticopontine_Tract_Parietal_L 49 65.4395 4.3711 982
Superior_Longitudinal_Fasciculus2_L 40 55.5082 5.31812 1233
Cingulum_Frontal_Parahippocampal_L 36 53.5589 3.89753 639
Dentatorubrothalamic_Tract_R 36 55.5621 5.1089 1139
Extreme_Capsule_L 18 59.1259 3.47884 562
Cingulum_Frontal_Parahippocampal_R 15 56.408 2.66649 315
Corticopontine_Tract_Parietal_R 13 60.3215 3.60294 615
Extreme_Capsule_R 12 53.1778 2.41705 244
Corpus_Callosum_Forceps_Major 12 62.6695 2.78586 382
Superior_Longitudinal_Fasciculus3_L 10 53.0228 2.9928 373
Corticostriatal_Tract_Posterior_R 10 54.2202 3.2795 458

peri

Positive Corrs (FDR = 0.317868)

No Significant Findings

Neg Corrs (FDR = 0.029057)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 330 65.9288 14.8677 11446
Corticospinal_Tract_R 247 65.1614 10.797 5966
Inferior_Fronto_Occipital_Fasciculus_R 237 62.9996 11.1414 6142
Corpus_Callosum_Tapetum 230 64.0876 12.4875 7849
Cerebellum_L 226 55.824 13.6766 8201
Superior_Longitudinal_Fasciculus2_R 222 63.6687 11.0012 6052
Arcuate_Fasciculus_R 217 68.5276 10.5223 5959
Middle_Cerebellar_Peduncle 194 61.8863 11.7635 6726
Corpus_Callosum_Forceps_Major 165 60.5409 10.4133 5156
Cingulum_Frontal_Parietal_R 164 67.6788 8.10524 3492
Corticostriatal_Tract_Posterior_R 164 65.9497 10.4386 5644
Arcuate_Fasciculus_L 156 58.5221 10.6119 5176
Dentatorubrothalamic_Tract_R 132 60.3919 10.8337 5567
Medial_Lemniscus_R 117 64.7779 8.32734 3528
Cerebellum_R 112 54.0119 11.2533 5372
Inferior_Fronto_Occipital_Fasciculus_L 107 63.858 8.71128 3806
Inferior_Longitudinal_Fasciculus_L 103 61.2768 8.57526 3539
Inferior_Longitudinal_Fasciculus_R 99 60.4508 9.74312 4507
Corticostriatal_Tract_Posterior_L 83 60.9943 8.90054 3795
Corticospinal_Tract_L 82 62.5653 7.91577 3079
Frontal_Aslant_Tract_L 80 61.3321 8.23794 3269
Corticopontine_Tract_Parietal_R 80 62.2362 7.68523 2887
Superior_Longitudinal_Fasciculus2_L 78 60.0313 8.49067 3399
Dentatorubrothalamic_Tract_L 77 58.3208 8.58 3372
Corticostriatal_Tract_Superior_L 65 57.147 8.1058 2949
Thalamic_Radiation_Posterior_R 63 60.3866 7.08243 2379
Thalamic_Radiation_Anterior_R 62 66.3354 6.61821 2282
Cingulum_Frontal_Parietal_L 58 60.6987 6.36768 1933
Corticostriatal_Tract_Superior_R 58 62.875 7.70151 2929
Corpus_Callosum_Forceps_Minor 58 61.6993 7.08284 2431
Medial_Lemniscus_L 56 58.516 6.31193 1831
Vermis 56 56.2245 6.62987 1941
Thalamic_Radiation_Superior_R 50 64.7278 7.14598 2596
Superior_Longitudinal_Fasciculus1_R 49 65.5205 5.81321 1739
Anterior_Commissure 45 65.2566 6.16506 1948
Extreme_Capsule_R 42 62.6303 5.72815 1614
Cingulum_Parahippocampal_Parietal_R 40 56.8632 5.66649 1434
Corticopontine_Tract_Parietal_L 38 65.4282 6.00172 1851
Reticular_Tract_R 36 62.3961 6.4393 2032
Superior_Longitudinal_Fasciculus3_R 31 60.652 5.2899 1333
Parietal_Aslant_Tract_L 29 58.9126 4.83128 1080
Corticopontine_Tract_Frontal_R 29 58.1488 5.48102 1372
Cingulum_Parolfactory_R 25 66.169 4.14528 893
Middle_Longitudinal_Fasciculus_R 23 58.529 5.07082 1182
Thalamic_Radiation_Posterior_L 22 58.7316 5.03631 1170
Extreme_Capsule_L 20 63.405 4.68279 1092
Optic_Radiation_L 17 55.7674 3.51125 540
Superior_Longitudinal_Fasciculus3_L 16 59.756 4.44671 928
Corticopontine_Tract_Occipital_R 16 64.6266 3.27979 546
Reticular_Tract_L 16 64.0179 4.49301 1015
Frontal_Aslant_Tract_R 13 53.6847 4.01 678
Parietal_Aslant_Tract_R 13 57.8639 3.78188 650
Corticopontine_Tract_Frontal_L 12 67.5064 3.65684 709
Cingulum_Parolfactory_L 11 60.1934 2.12261 213
Thalamic_Radiation_Superior_L 11 62.7421 3.76899 700
Cingulum_Frontal_Parahippocampal_R 10 68.0192 3.07153 504
Middle_Longitudinal_Fasciculus_L 10 56.2141 3.62761 581

post

Positive Corrs (FDR = 1.000000)

No Significant Findings

Neg Corrs (FDR = 0.302332)

No Significant Findings

Peri + Post

Positive Corrs (FDR = 0.082506)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 681 58.7354 11.7131 6329
Corpus_Callosum_Body 366 56.2798 12.6399 7062
Middle_Cerebellar_Peduncle 306 59.0543 10.7821 5392
Corpus_Callosum_Forceps_Major 173 61.4656 7.70776 2868
Corpus_Callosum_Tapetum 157 54.9597 8.07268 2813
Inferior_Fronto_Occipital_Fasciculus_R 83 55.7638 6.1006 1630
Uncinate_Fasciculus_R 55 57.9419 4.89184 1089
Cingulum_Frontal_Parietal_L 47 56.1396 3.59549 570
Cerebellum_L 42 53.2038 3.941 649
Cingulum_Frontal_Parietal_R 40 58.206 4.37497 875
Cingulum_Parolfactory_L 32 53.8777 2.88008 351
Cingulum_Parolfactory_R 29 57.8008 2.84716 368
Inferior_Longitudinal_Fasciculus_R 14 52.2868 2.95257 358
Thalamic_Radiation_Anterior_R 13 55.0804 3.24311 455

Neg Corrs (FDR = 0.081279)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Forceps_Minor 920 66.7952 14.7981 11488
Corpus_Callosum_Body 803 65.7615 16.6946 14395
Corpus_Callosum_Forceps_Major 538 70.7981 12.2352 8324
Cerebellum_R 495 56.2048 13.646 8220
Corpus_Callosum_Tapetum 404 63.2638 12.3203 7542
Corticospinal_Tract_R 392 62.4423 8.81294 3809
Arcuate_Fasciculus_L 222 56.3231 9.9914 4416
Inferior_Fronto_Occipital_Fasciculus_L 207 62.323 8.92155 3896
Medial_Lemniscus_R 167 57.1932 8.1491 2983
Inferior_Longitudinal_Fasciculus_L 149 62.3197 7.67076 2880
Corticostriatal_Tract_Superior_R 98 55.2739 6.75859 1983
Corticostriatal_Tract_Posterior_L 83 63.6939 8.10229 3284
Thalamic_Radiation_Posterior_R 79 59.1474 6.56477 2002
Cerebellum_L 75 54.2486 7.18739 2201
Corticospinal_Tract_L 74 59.3102 6.48496 1959
Superior_Longitudinal_Fasciculus2_R 73 57.1082 5.34 1279
Thalamic_Radiation_Posterior_L 67 57.5649 6.86221 2129
Corticostriatal_Tract_Posterior_R 64 58.229 6.87087 2159
Cingulum_Frontal_Parietal_L 62 61.1051 5.84037 1637
Middle_Longitudinal_Fasciculus_R 62 54.7522 6.35008 1734
Cingulum_Frontal_Parietal_R 58 57.013 5.1378 1182
Inferior_Fronto_Occipital_Fasciculus_R 54 55.2686 6.21744 1678
Corticostriatal_Tract_Superior_L 50 53.9601 5.27443 1179
Extreme_Capsule_L 49 59.56 5.9696 1667
Arcuate_Fasciculus_R 40 56.4534 5.1632 1182
Extreme_Capsule_R 40 56.0137 4.54058 907
Corticopontine_Tract_Parietal_R 34 58.8266 5.97962 1652
Middle_Longitudinal_Fasciculus_L 33 56.3185 4.13692 757
Cingulum_Parolfactory_L 31 58.2019 4.34502 863
Medial_Lemniscus_L 30 56.7371 4.62938 955
Dentatorubrothalamic_Tract_R 28 53.5793 5.02364 1062
Corticopontine_Tract_Parietal_L 24 59.4321 5.07032 1200
Thalamic_Radiation_Anterior_R 24 59.1752 4.15147 801
Superior_Longitudinal_Fasciculus1_L 19 56.8632 3.08122 424
Corticostriatal_Tract_Anterior_L 19 54.2121 3.74137 596
Dentatorubrothalamic_Tract_L 19 53.5778 4.12783 717
Cingulum_Parolfactory_R 18 57.7912 2.75298 344
Thalamic_Radiation_Anterior_L 18 55.1118 3.74787 608
Thalamic_Radiation_Superior_R 17 55.1917 3.63259 572
Cingulum_Frontal_Parahippocampal_R 15 58.8151 3.4159 539
Corticopontine_Tract_Occipital_L 11 58.3899 2.53628 295
Corticostriatal_Tract_Anterior_R 11 54.1962 3.5353 532
Anterior_Commissure 11 51.8178 3.15069 404
Corticopontine_Tract_Occipital_R 10 56.62 2.73237 332

MD

Summary

All subjects

Positive Corrs (FDR = 0.052632)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 14 54.0197 3.34248 474

Neg Corrs (FDR = 0.001083)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 385 56.2115 7.25851 2326
Fornix_L 359 55.8681 8.22718 2970
Thalamic_Radiation_Superior_L 21 54.4852 3.44885 509

Men

Positive Corrs (FDR = 0.052789)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1565 58.822 9.85954 4491
Fornix_R 252 55.9948 7.25689 2316
Thalamic_Radiation_Superior_L 110 56.39 6.15898 1680
Thalamic_Radiation_Superior_R 11 57.0999 2.44914 269
Corpus_Callosum_Forceps_Major 10 53.2237 3.24436 440
Cerebellum_L 10 52.8089 2.50373 260

Neg Corrs (FDR = 1.000000)

Not significant

Women

Positive Corrs (FDR = 1.000000)

Not significant

Neg Corrs (FDR = 0.000594)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 790 55.9141 9.18768 3707
Fornix_R 298 55.11 6.73613 1964
Corpus_Callosum_Tapetum 112 60.6023 6.4171 1960
Corpus_Callosum_Body 106 57.9578 5.31933 1288
Thalamic_Radiation_Superior_L 78 53.3173 5.43288 1236
Optic_Radiation_L 29 54.8945 3.35399 485
Cingulum_Frontal_Parietal_L 11 54.5619 1.51225 98
Corpus_Callosum_Forceps_Major 10 53.6157 2.34722 232

pre

Positive Corrs (FDR = 1.000000)

Not significant

Neg Corrs (FDR = 0.027414)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 593 60.8483 8.51618 3466
Fornix_R 229 57.3531 5.34522 1287
Cerebellum_R 63 54.2347 4.15111 734
Thalamic_Radiation_Superior_L 36 53.8466 3.98621 672
Corpus_Callosum_Body 36 64.507 4.33708 953
Corpus_Callosum_Tapetum 36 59.8425 4.25515 851
Corpus_Callosum_Forceps_Major 31 55.6306 4.18162 764
Cingulum_Frontal_Parietal_L 17 55.0485 1.72734 129

peri

Positive Corrs (FDR = 1.000000)

Not significant

Neg Corrs (FDR = 0.018769)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 136 61.3216 9.20066 4077
Corpus_Callosum_Forceps_Major 125 61.5881 10.2136 5046
Cerebellum_R 96 54.6717 8.23653 2913
Corpus_Callosum_Body 94 63.0077 8.48647 3564
Fornix_L 89 62.0309 6.68314 2176
Corticostriatal_Tract_Posterior_R 71 56.0654 7.4759 2461
Inferior_Longitudinal_Fasciculus_R 63 62.7407 7.7058 2926
Corpus_Callosum_Forceps_Minor 47 59.0682 6.8029 2147
Cerebellum_L 44 53.5571 6.30093 1670
Arcuate_Fasciculus_R 30 58.1423 5.17726 1224
Inferior_Fronto_Occipital_Fasciculus_L 26 60.3186 5.16947 1266
Inferior_Fronto_Occipital_Fasciculus_R 25 57.9908 4.96774 1124
Arcuate_Fasciculus_L 23 55.6588 4.4714 874
Thalamic_Radiation_Superior_L 23 58.2649 3.96659 720
Fornix_R 23 61.9287 3.69203 663
Dentatorubrothalamic_Tract_L 21 55.6267 4.9396 1066
Middle_Cerebellar_Peduncle 21 63.6313 4.1507 861
Inferior_Longitudinal_Fasciculus_L 19 59.3809 4.15976 807
Dentatorubrothalamic_Tract_R 16 58.7448 3.74475 647
Optic_Radiation_L 14 55.7199 3.83613 644
Anterior_Commissure 14 57.5897 3.66635 608
Corticostriatal_Tract_Posterior_L 13 57.4001 3.65424 602
Thalamic_Radiation_Posterior_R 11 54.8985 3.79813 622
Reticular_Tract_L 11 64.9192 2.82183 406
Cingulum_Frontal_Parietal_L 10 61.3974 2.95475 421
Superior_Longitudinal_Fasciculus2_L 10 59.0103 3.38803 532
Corticospinal_Tract_L 10 53.4043 3.26818 448

post

Positive Corrs (FDR = 1.000000)

No Significant Findings

Neg Corrs (FDR = 0.289057)

No Significant Findings

Peri + Post

Positive Corrs (FDR = 1.000000)

No Significant Findings

Neg Corrs (FDR = 0.187319)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 923 57.9248 10.231 4762
Corpus_Callosum_Tapetum 860 60.3349 12.8388 7811
Fornix_R 305 56.5731 7.42714 2451
Cerebellum_R 143 53.405 7.3744 2281
Corpus_Callosum_Body 124 59.1681 7.52153 2629
Thalamic_Radiation_Superior_L 115 58.4374 6.05373 1682
Corpus_Callosum_Forceps_Major 114 58.4289 7.64203 2680
Inferior_Longitudinal_Fasciculus_R 45 56.8591 5.2503 1231
Inferior_Fronto_Occipital_Fasciculus_L 31 54.8414 4.20885 763
Corticostriatal_Tract_Posterior_R 23 54.7086 4.0073 690
Inferior_Longitudinal_Fasciculus_L 20 53.5151 3.94463 654
Cingulum_Frontal_Parietal_L 16 55.1192 2.81892 344
Cingulum_Frontal_Parahippocampal_L 15 62.6689 3.68674 669
Middle_Cerebellar_Peduncle 15 53.2047 2.78883 325
Arcuate_Fasciculus_L 13 56.4665 2.93872 383
Optic_Radiation_L 10 54.6088 2.7485 324

AD

Summary

All subjects

Positive Corrs (FDR = 0.083333)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 8 51.5 2.59796 273

Neg Corrs (FDR = 0.000569)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 472 56.3187 7.11627 2240
Fornix_L 323 54.2544 7.13292 2168

Men

Positive Corrs (FDR = 0.039599)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 690 56.4607 8.79998 3434
Fornix_R 138 55.5946 6.14725 1650
Thalamic_Radiation_Superior_L 57 55.5539 4.92425 1058
Cerebellum_L 17 51.8947 3.0211 372

Neg Corrs (FDR = 1.000000)

Not significant

Women

Positive Corrs (FDR = 1.000000)

Not significant

Neg Corrs (FDR = 0.000311)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 777 54.7772 8.79522 3328
Fornix_R 264 54.5156 6.55368 1839
Corpus_Callosum_Tapetum 136 56.5829 6.99748 2176
Thalamic_Radiation_Superior_L 100 53.4262 5.89665 1459
Optic_Radiation_L 28 55.6513 3.34823 490
Inferior_Fronto_Occipital_Fasciculus_L 21 55.3451 3.17796 439
Cingulum_Frontal_Parietal_L 14 54.7235 2.79601 336

pre

Positive Corrs (FDR = 1.000000)

Not significant

Neg Corrs (FDR = 0.035371)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1685 59.6412 11.5233 6220
Fornix_R 1199 58.0065 10.0276 4581
Corpus_Callosum_Forceps_Major 351 60.8296 9.85713 4642
Cerebellum_R 343 54.2152 9.31793 3697
Corpus_Callosum_Tapetum 324 59.1429 13.2743 8185
Thalamic_Radiation_Superior_L 158 54.0044 7.4133 2331
Optic_Radiation_L 146 55.9949 7.06959 2198
Corpus_Callosum_Body 86 54.8251 8.86373 3383
Corticospinal_Tract_L 49 55.8454 5.16702 1171
Thalamic_Radiation_Superior_R 48 55.0106 4.64202 931
Arcuate_Fasciculus_R 45 56.1465 4.53021 905
Corticostriatal_Tract_Posterior_R 44 56.4236 5.83925 1511
Dentatorubrothalamic_Tract_R 40 57.4546 4.72397 1007
Cingulum_Frontal_Parietal_L 39 55.5984 4.54493 902
Thalamic_Radiation_Posterior_R 39 58.4165 5.03907 1165
Inferior_Fronto_Occipital_Fasciculus_L 33 55.948 5.08678 1137
Corticospinal_Tract_R 29 56.0753 4.36206 838
Corticostriatal_Tract_Posterior_L 28 54.7354 3.75454 606
Anterior_Commissure 28 58.0158 4.26282 828
Inferior_Longitudinal_Fasciculus_L 17 56.1331 3.96757 694
Superior_Longitudinal_Fasciculus1_L 16 58.0123 3.06132 427
Cingulum_Frontal_Parahippocampal_L 14 69.2925 2.70429 398
Optic_Radiation_R 14 53.5805 2.33276 229
Dentatorubrothalamic_Tract_L 13 55.706 3.34317 489
Corticopontine_Tract_Occipital_R 11 55.265 2.91175 368
Inferior_Fronto_Occipital_Fasciculus_R 10 60.6201 3.06408 447
Inferior_Longitudinal_Fasciculus_R 10 61.2367 3.28181 518

peri

Positive Corrs (not significant) (FDR = 1.000000)

Not significant

Neg Corrs (FDR = 0.007165)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 212 67.5974 10.4782 5829
Cerebellum_R 94 54.625 8.35382 2994
Corpus_Callosum_Forceps_Major 88 62.3296 8.0496 3172
Fornix_L 83 60.9278 6.24123 1864
Corpus_Callosum_Body 52 59.3152 6.76179 2130
Cerebellum_L 50 53.7267 6.39003 1723
Inferior_Longitudinal_Fasciculus_L 49 56.9462 6.02396 1623
Middle_Cerebellar_Peduncle 37 54.5994 5.91829 1502
Corticostriatal_Tract_Posterior_R 36 57.7391 6.2316 1761
Arcuate_Fasciculus_R 35 62.9293 5.21081 1342
Fornix_R 35 65.9522 4.34742 979
Optic_Radiation_L 33 58.37 4.97574 1135
Corticospinal_Tract_R 32 60.7648 5.09935 1241
Inferior_Fronto_Occipital_Fasciculus_R 31 56.7111 6.01408 1611
Inferior_Longitudinal_Fasciculus_R 29 58.7034 6.07044 1699
Dentatorubrothalamic_Tract_R 27 59.7927 5.75435 1555
Inferior_Fronto_Occipital_Fasciculus_L 24 58.4147 4.74738 1034
Corticospinal_Tract_L 21 57.9135 4.18858 798
Corticopontine_Tract_Parietal_L 20 60.7126 3.50861 587
Corticostriatal_Tract_Posterior_L 19 55.3643 4.35051 823
Dentatorubrothalamic_Tract_L 18 56.9022 4.28871 822
Cingulum_Parolfactory_R 17 62.5969 3.65562 657
Superior_Longitudinal_Fasciculus2_L 17 55.6631 3.65492 584
Thalamic_Radiation_Posterior_R 17 57.543 4.43517 889
Thalamic_Radiation_Posterior_L 15 57.475 4.24907 815
Medial_Lemniscus_R 15 60.4071 3.8274 695
Arcuate_Fasciculus_L 14 59.4428 4.17302 813
Thalamic_Radiation_Anterior_R 13 53.0881 3.64182 553
Middle_Longitudinal_Fasciculus_R 12 53.0105 3.72918 579
Corticopontine_Tract_Parietal_R 12 55.497 3.60035 565
Thalamic_Radiation_Superior_L 12 56.0158 3.49046 536
Corpus_Callosum_Forceps_Minor 12 58.5037 3.49417 561
Cingulum_Frontal_Parietal_R 11 55.8333 3.44358 520
Superior_Longitudinal_Fasciculus2_R 10 54.6162 3.33467 477

post

Positive Corrs (FDR = 1.000000)

No Significant Findings

Neg Corrs (FDR = 0.168946)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Cerebellum_R 102 55.3647 8.8113 3376
Cerebellum_L 78 53.7846 8.25844 2881
Fornix_L 53 59.0651 5.53071 1419
Corpus_Callosum_Forceps_Major 38 57.5914 5.26532 1254
Thalamic_Radiation_Superior_L 35 62.9714 3.39783 571
Corpus_Callosum_Tapetum 30 57.8706 6.05975 1669
Corpus_Callosum_Body 20 54.9034 4.54563 891
Inferior_Fronto_Occipital_Fasciculus_R 17 51.8985 4.60665 865
Middle_Cerebellar_Peduncle 15 57.7442 3.59459 586
Medial_Lemniscus_R 14 57.1366 2.99303 402
Arcuate_Fasciculus_L 13 51.3937 3.6745 545
Inferior_Longitudinal_Fasciculus_R 13 53.2487 3.60662 544
Corticostriatal_Tract_Superior_R 12 54.1956 2.8757 352
Cingulum_Parolfactory_R 10 56.2217 2.9528 385
Fornix_R 10 58.7948 3.10082 444

Peri + Post

Positive Corrs (FDR = 1.000000)

No significant

Neg Corrs (FDR = 0.059775)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Tapetum 355 58.6514 10.0255 4630
Fornix_L 257 56.1715 7.16683 2266
Corpus_Callosum_Body 115 55.7838 6.23459 1703
Corpus_Callosum_Forceps_Major 101 58.46 6.11876 1719
Cerebellum_R 91 53.1717 5.87621 1442
Fornix_R 86 55.1965 4.78601 993
Thalamic_Radiation_Superior_L 64 55.7154 5.38303 1268
Inferior_Fronto_Occipital_Fasciculus_L 18 55.0104 2.87453 357
Cingulum_Frontal_Parietal_L 13 57.842 2.81113 359

RD

Summary

All subjects

Positive Corrs (FDR = 0.050000)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 14 53.7203 3.04421 391

Neg Corrs (FDR = 0.000506)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_R 389 55.8954 6.84517 2057
Fornix_L 361 56.3367 7.97908 2817
Thalamic_Radiation_Superior_L 16 53.3834 2.84349 339

Men

Positive Corrs (FDR = 0.040025)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 1041 59.0382 8.75236 3552
Fornix_R 133 56.5103 5.64637 1415
Thalamic_Radiation_Superior_L 60 55.3754 5.18668 1170
Corpus_Callosum_Forceps_Major 11 51.8294 3.13079 399

Neg Corrs (FDR = 1.000000)

Not significant

Women

Positive Corrs (FDR = 1.000000)

Not significant

Neg Corrs (FDR = 0.000631)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 803 56.0847 9.28072 3794
Fornix_R 324 54.8724 6.761 1970
Corpus_Callosum_Body 77 54.1434 5.49924 1286
Corpus_Callosum_Tapetum 56 59.6825 4.82883 1093
Thalamic_Radiation_Superior_L 50 53.7264 4.64389 910
Cingulum_Frontal_Parietal_L 17 54.8275 1.56153 105

pre

Positive Corrs (FDR = 1.000000)

Not significant

Neg Corrs (FDR = 0.030260)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Fornix_L 637 60.8372 8.79263 3694
Fornix_R 258 57.824 5.78906 1522
Corpus_Callosum_Tapetum 36 58.8379 4.04203 755
Corpus_Callosum_Body 30 63.9396 3.80223 726
Corpus_Callosum_Forceps_Major 29 58.9119 4.25828 839
Cerebellum_R 28 53.5071 3.36199 475
Thalamic_Radiation_Superior_L 18 54.2306 3.03372 392
Cingulum_Frontal_Parietal_L 13 52.9322 1.85465 143

peri

Positive Corrs (FDR = 1.000000)

Not significant

Neg Corrs (FDR = 0.017967)

Tract Name number of tracts mean length(mm) diameter(mm) volume(mm^3)
Corpus_Callosum_Body 128 60.2305 9.82567 4567
Corpus_Callosum_Forceps_Major 102 60.6943 9.13395 3977
Corpus_Callosum_Tapetum 98 61.7859 8.18626 3252
Fornix_L 94 62.3784 6.54864 2101
Cerebellum_R 68 54.0638 7.70528 2521
Corpus_Callosum_Forceps_Minor 63 57.4765 7.41798 2484
Cerebellum_L 52 53.2363 7.05992 2084
Fornix_R 26 59.4028 3.45215 556
Inferior_Longitudinal_Fasciculus_R 25 60.0235 5.08923 1221
Thalamic_Radiation_Posterior_R 22 54.6439 4.78587 983
Corticostriatal_Tract_Posterior_R 19 53.2758 4.93004 1017
Dentatorubrothalamic_Tract_L 19 57.056 4.15599 774
Arcuate_Fasciculus_R 16 55.5145 4.2296 780
Thalamic_Radiation_Superior_L 15 63.0769 3.66104 664
Middle_Cerebellar_Peduncle 14 60.8666 3.74092 669
Reticular_Tract_R 13 57.087 3.24113 471
Reticular_Tract_L 12 62.4961 3.26422 523
Cingulum_Parolfactory_R 10 65.8215 2.12755 234
Corticospinal_Tract_L 10 57.4239 2.72947 336

post

Positive Corrs (FDR = 1.000000)

No Significant Findings

Neg Corrs (FDR = 0.273451)

No Significant Findings

Peri + Post

Positive Corrs (FDR = 1.000000)

No significant

Neg Corrs (FDR = 0.231903)

No significant

Loop Angular error average

QA

All subjects

Men

Women

pre

peri

post

MD

All subjects

Men

Women

pre

peri

post

AD

All subjects

Men

Women

pre

peri

post

RD

All subjects

Men

Women

pre

peri

post